Pediatric osteosarcoma. Long-term results of neoadjuvant treatment

A. Brach del Prever, L. Besenzon, A. Pineschi, R. Marinoni, G. Bacci, P. Picci

Research output: Contribution to journalArticlepeer-review


The introduction of preoperative chemotherapy has significantly modified the therapy and prognosis of osteosarcoma. The authors report the results of two consecutive protocols of neoadjuvant chemotherapy for localized osteosarcoma of the extremities in childhood and adolescence. From 1984 to 1989, 46 patients (22 male and 24 female) with a median age of 11 years and 11 months were treated. Limb salvage was possible in 33 patients (72%); 8 patients (17%) underwent amputation, and in 5 (11%) rotation plasty was performed. The percentage of tumor necrosis was ≤ 90% in 31 children (67%), 60 to 89% in 12 (26%) and ≤ 60% in 3 (7%). At present 32 patients are alive: 27 are continuously disease-free 85 to 151 months after diagnosis; 5 are alive without signs of disease after having shown a relapse of the tumor. Twelve patients died of progressive disease, 1 of severe toxicity without signs of disease and 1 of a second tumor without evidence of osteosarcoma. At 3 and 7 years from diagnosis the overall survival rates are 85 and 74%, respectively. At the same interval the continuous disease-free survival rates are 66 and 61%.

Original languageEnglish
Pages (from-to)353-366
Number of pages14
JournalInternational Journal of Pediatric Hematology/Oncology
Issue number5
Publication statusPublished - 1998


  • Limb salvage
  • Neoadjuvant chemotherapy
  • Osteosarcoma
  • Pediatric tumors
  • Survival rate

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Pediatric osteosarcoma. Long-term results of neoadjuvant treatment'. Together they form a unique fingerprint.

Cite this