Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Giulio Kleiner, Valentina Zanin, Lorenzo Monasta, Sergio Crovella, Lorenzo Caruso, Daniela Milani, Annalisa Marcuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of the gastrointestinal tract. Although the causative events that lead to the onset of IBD are yet to be fully elucidated, deregulation of immune and inflammatory mechanisms are hypothesized to significantly contribute to this disorder. Since the onset of IBD is often during infancy, in the present study, the serum values of a large panel of cytokines and chemokines in pediatric patients (

Original languageEnglish
Pages (from-to)2047-2052
Number of pages6
JournalExperimental and Therapeutic Medicine
Volume9
Issue number6
DOIs
Publication statusPublished - 2015

Keywords

  • Chemokines
  • Cytokines
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

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