TY - JOUR
T1 - Pediatric pituitary adenoma with mixed FSH and TSH immunostaining and FSH hypersecretion in a 6 year-old girl with precocious puberty: case report and multidisciplinary management
T2 - International Journal of Neuroscience
AU - Ceraudo, M.
AU - Criminelli Rossi, D.
AU - Di Iorgi, N.
AU - Cama, A.
AU - Piatelli, G.
AU - Consales, A.
PY - 2020
Y1 - 2020
N2 - Objective: We describe a rare case of functioning gonadotropins-producing pediatric adenoma immunostaining positively for FSH and focally for TSH causing central precocious puberty associated to central hypothyroidism in a 6 year-old girl. Materials and Methods: Clinical evaluation revealed precocious puberty, as confirmed by hormonal determination with elevated FSH and estradiol, while central hypothyroidism was biochemically diagnosed by a low fT4 and normal TSH. Head MRI showed the presence of a hyperintense pituitary lesion. The patient successfully underwent transsphenoidal endoscopic resection of the pituitary macroadenoma. Results: Pathologic evaluation of the tissue resected at surgery confirmed the diagnosis of pituitary adenoma with positive immunohistochemistry for FSH and focally for TSH in a mixed pattern. Ten months after surgery, there were no neurological signs and symptoms. Postoperative head MRI showed no abnormalities and no evidence of tumor regrowth. Conclusions: Early and accurate diagnosis, multidisciplinary approach and close follow up are crucial factors for the favorable outcome. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
AB - Objective: We describe a rare case of functioning gonadotropins-producing pediatric adenoma immunostaining positively for FSH and focally for TSH causing central precocious puberty associated to central hypothyroidism in a 6 year-old girl. Materials and Methods: Clinical evaluation revealed precocious puberty, as confirmed by hormonal determination with elevated FSH and estradiol, while central hypothyroidism was biochemically diagnosed by a low fT4 and normal TSH. Head MRI showed the presence of a hyperintense pituitary lesion. The patient successfully underwent transsphenoidal endoscopic resection of the pituitary macroadenoma. Results: Pathologic evaluation of the tissue resected at surgery confirmed the diagnosis of pituitary adenoma with positive immunohistochemistry for FSH and focally for TSH in a mixed pattern. Ten months after surgery, there were no neurological signs and symptoms. Postoperative head MRI showed no abnormalities and no evidence of tumor regrowth. Conclusions: Early and accurate diagnosis, multidisciplinary approach and close follow up are crucial factors for the favorable outcome. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
KW - RIS
U2 - 10.1080/00207454.2020.1815734
DO - 10.1080/00207454.2020.1815734
M3 - Article
JO - Int. J. Neurosci.
JF - Int. J. Neurosci.
SN - 0020-7454
ER -