Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

Mariangela Pierantozzi, Maria Giuseppina Palmieri, Salvatore Galati, Paolo Stanzione, Antonella Peppe, Domenicantonio Tropepi, Livia Brusa, Antonio Pisani, Vincenzo Moschella, Maria Grazia Marciani, Paolo Mazzone, Alessandro Stefani

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

Original languageEnglish
Pages (from-to)731-735
Number of pages5
JournalJournal of Neural Transmission
Volume115
Issue number5
DOIs
Publication statusPublished - May 2008

Fingerprint

Spinal Cord Stimulation
Deep Brain Stimulation
Parkinson Disease
Abnormal Reflexes
Subthalamic Nucleus
Levodopa
Basal Ganglia
Brain Stem
Reflex

Keywords

  • Deep brain stimulation
  • Hoffman Roflex
  • Pedunculopontine nucleus
  • Spinal cord excitability

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. / Pierantozzi, Mariangela; Palmieri, Maria Giuseppina; Galati, Salvatore; Stanzione, Paolo; Peppe, Antonella; Tropepi, Domenicantonio; Brusa, Livia; Pisani, Antonio; Moschella, Vincenzo; Marciani, Maria Grazia; Mazzone, Paolo; Stefani, Alessandro.

In: Journal of Neural Transmission, Vol. 115, No. 5, 05.2008, p. 731-735.

Research output: Contribution to journalArticle

Pierantozzi, M, Palmieri, MG, Galati, S, Stanzione, P, Peppe, A, Tropepi, D, Brusa, L, Pisani, A, Moschella, V, Marciani, MG, Mazzone, P & Stefani, A 2008, 'Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients', Journal of Neural Transmission, vol. 115, no. 5, pp. 731-735. https://doi.org/10.1007/s00702-007-0001-8
Pierantozzi, Mariangela ; Palmieri, Maria Giuseppina ; Galati, Salvatore ; Stanzione, Paolo ; Peppe, Antonella ; Tropepi, Domenicantonio ; Brusa, Livia ; Pisani, Antonio ; Moschella, Vincenzo ; Marciani, Maria Grazia ; Mazzone, Paolo ; Stefani, Alessandro. / Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. In: Journal of Neural Transmission. 2008 ; Vol. 115, No. 5. pp. 731-735.
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