Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

Mariangela Pierantozzi; Maria Giuseppina Palmieri; Salvatore Galati; Paolo Stanzione; Antonella Peppe; Domenicantonio Tropepi; Livia Brusa; Antonio Pisani; Vincenzo Moschella; Maria Grazia Marciani; Paolo Mazzone; Alessandro Stefani

doi:10.1007/s00702-007-0001-8

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

Mariangela Pierantozzi, Maria Giuseppina Palmieri, Salvatore Galati, Paolo Stanzione, Antonella Peppe, Domenicantonio Tropepi, Livia Brusa, Antonio Pisani, Vincenzo Moschella, Maria Grazia Marciani, Paolo Mazzone, Alessandro Stefani

Fondazione Santa Lucia

Research output: Contribution to journal › Article

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

Original language	English
Pages (from-to)	731-735
Number of pages	5
Journal	Journal of Neural Transmission
Volume	115
Issue number	5
DOIs	https://doi.org/10.1007/s00702-007-0001-8
Publication status	Published - May 2008

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Keywords

Deep brain stimulation
Hoffman Roflex
Pedunculopontine nucleus
Spinal cord excitability

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Pierantozzi, M., Palmieri, M. G., Galati, S., Stanzione, P., Peppe, A., Tropepi, D., Brusa, L., Pisani, A., Moschella, V., Marciani, M. G., Mazzone, P., & Stefani, A. (2008). Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. Journal of Neural Transmission, 115(5), 731-735. https://doi.org/10.1007/s00702-007-0001-8

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. / Pierantozzi, Mariangela; Palmieri, Maria Giuseppina; Galati, Salvatore; Stanzione, Paolo; Peppe, Antonella; Tropepi, Domenicantonio; Brusa, Livia; Pisani, Antonio; Moschella, Vincenzo; Marciani, Maria Grazia; Mazzone, Paolo; Stefani, Alessandro.

In: Journal of Neural Transmission, Vol. 115, No. 5, 05.2008, p. 731-735.

Research output: Contribution to journal › Article

Pierantozzi, M, Palmieri, MG, Galati, S, Stanzione, P, Peppe, A, Tropepi, D, Brusa, L, Pisani, A, Moschella, V, Marciani, MG, Mazzone, P & Stefani, A 2008, 'Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients', Journal of Neural Transmission, vol. 115, no. 5, pp. 731-735. https://doi.org/10.1007/s00702-007-0001-8

Pierantozzi, Mariangela ; Palmieri, Maria Giuseppina ; Galati, Salvatore ; Stanzione, Paolo ; Peppe, Antonella ; Tropepi, Domenicantonio ; Brusa, Livia ; Pisani, Antonio ; Moschella, Vincenzo ; Marciani, Maria Grazia ; Mazzone, Paolo ; Stefani, Alessandro. / Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. In: Journal of Neural Transmission. 2008 ; Vol. 115, No. 5. pp. 731-735.

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10.1007/s00702-007-0001-8