Abstract
Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
| Original language | English |
|---|---|
| Pages (from-to) | 731-735 |
| Number of pages | 5 |
| Journal | Journal of Neural Transmission |
| Volume | 115 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- Deep brain stimulation
- Hoffman Roflex
- Pedunculopontine nucleus
- Spinal cord excitability
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. / Pierantozzi, Mariangela; Palmieri, Maria Giuseppina; Galati, Salvatore; Stanzione, Paolo; Peppe, Antonella; Tropepi, Domenicantonio; Brusa, Livia; Pisani, Antonio; Moschella, Vincenzo; Marciani, Maria Grazia; Mazzone, Paolo; Stefani, Alessandro.
In: Journal of Neural Transmission, Vol. 115, No. 5, 05.2008, p. 731-735.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients
AU - Pierantozzi, Mariangela
AU - Palmieri, Maria Giuseppina
AU - Galati, Salvatore
AU - Stanzione, Paolo
AU - Peppe, Antonella
AU - Tropepi, Domenicantonio
AU - Brusa, Livia
AU - Pisani, Antonio
AU - Moschella, Vincenzo
AU - Marciani, Maria Grazia
AU - Mazzone, Paolo
AU - Stefani, Alessandro
PY - 2008/5
Y1 - 2008/5
N2 - Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
AB - Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
KW - Deep brain stimulation
KW - Hoffman Roflex
KW - Pedunculopontine nucleus
KW - Spinal cord excitability
UR - http://www.scopus.com/inward/record.url?scp=44749090395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44749090395&partnerID=8YFLogxK
U2 - 10.1007/s00702-007-0001-8
DO - 10.1007/s00702-007-0001-8
M3 - Article
VL - 115
SP - 731
EP - 735
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 5
ER -