TY - JOUR
T1 - Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients
AU - Pierantozzi, Mariangela
AU - Palmieri, Maria Giuseppina
AU - Galati, Salvatore
AU - Stanzione, Paolo
AU - Peppe, Antonella
AU - Tropepi, Domenicantonio
AU - Brusa, Livia
AU - Pisani, Antonio
AU - Moschella, Vincenzo
AU - Marciani, Maria Grazia
AU - Mazzone, Paolo
AU - Stefani, Alessandro
PY - 2008/5
Y1 - 2008/5
N2 - Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
AB - Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.
KW - Deep brain stimulation
KW - Hoffman Roflex
KW - Pedunculopontine nucleus
KW - Spinal cord excitability
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U2 - 10.1007/s00702-007-0001-8
DO - 10.1007/s00702-007-0001-8
M3 - Article
C2 - 18196202
AN - SCOPUS:44749090395
VL - 115
SP - 731
EP - 735
JO - Journal of Neuro-Visceral Relations
JF - Journal of Neuro-Visceral Relations
SN - 0375-9245
IS - 5
ER -