Pegaptanib: choroidal neovascularization in patients with age-related macular degeneration and previous arterial thromboembolic events

Maurizio Battaglia Parodi, Emanuele Di Bartolo, Claudia Brue, Ezio Cappello, Claudio Furino, Sebastiano Giuffrida, Manuela Imparato, Michele Reibaldi

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate the efficacy and the rate of side effects of the pegylated aptamer pegaptanib in the treatment of patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and a history of previous arterial thromboembolic events (ATEs).

METHODS: Twenty-three eyes of 23 patients with subfoveal CNV due to AMD and cerebrovascular accidents (n = 12) and myocardial infarction (n = 11) in the previous 6 months received intravitreal pegaptanib 0.3 mg according to a pro re nata regimen and were followed for 12 months. The paired Student t test was used to evaluate mean changes in best-corrected visual acuity (BCVA; primary outcome measure) and central foveal thickness (CFT).

RESULTS: The mean patient age was 71.5 ± 4.6 years; there were 14 women and 9 men. The CNV was type 1, 2, and 3 in 18, 3, and 2 eyes, respectively. The mean BCVA improved from 0.67 ± 0.23 logMAR at baseline to 0.52 ± 0.31 logMAR at the end of 12-month follow-up (p = 0.044). Thirty-five percent of patients achieved ≥3 Early Treatment Diabetic Retinopathy Study lines improvement at 12 months. Mean CFT at baseline (381 ± 111 µm) decreased to 304 ± 82 µm at 12 months (p = 0.008). Patients received a mean of 4.3 ± 1.3 (range 3-7) injections. No systemic or ocular side effects occurred; no patient experienced further ATEs.

CONCLUSIONS: Intravitreal pegaptanib can be considered a viable treatment option for patients with AMD-related CNV who are at high risk of ATEs.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalEuropean Journal of Ophthalmology
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Age-related macular degeneration
  • Choroidal neovascularization
  • Pegaptanib
  • Thromboembolism

ASJC Scopus subject areas

  • Ophthalmology

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