Abstract
The inclusion of poly(ethylene glycol) monolaurate in liposomes formulated with dimyristoyl-sn-glycero-3-phosphocholine and certain cationic gemini surfactants improves their capability of condensing DNA into a ψ phase and transfecting it into cells. Both the condensation, observed by circular dichroism, and the transfection efficiency are strongly effected by the protocol of inclusion of the polymer in the formulations. The highest transfection efficiency is observed in correspondence of the highest extent of DNA condensation.
Original language | English |
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Pages (from-to) | 6274-6278 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 50 |
Issue number | 24 |
DOIs | |
Publication status | Published - Nov 29 2007 |
ASJC Scopus subject areas
- Organic Chemistry