Pegylated liposomal doxorubicin combined with carboplatin: A rational treatment choice for advanced ovarian cancer

Sandro Pignata, Eric Pujade Lauraine, Andreas du Bois, Carmela Pisano

Research output: Contribution to journalArticle

Abstract

Objective: Many questions remain unanswered regarding the optimal treatment paradigm for ovarian cancer, and alternatives for both firstand second-line therapy are needed. Methods: This review summarizes recent data with the combination of pegylated liposomal doxorubicin (PLD) and carboplatin in ovarian cancer. Results: Anthracyclines are active in ovarian cancer and lack the neurotoxic effects of taxanes. PLD has reduced cardiotoxic potential vs non-liposomal doxorubicin and is the only non-platinum monotherapy to demonstrate a significant survival advantage as second-line treatment of ovarian cancer. Replacing the taxane with PLD in platinum doublets for either first-line or recurrent ovarian cancer (ROC) has been or is being evaluated in more than 1600 patients. Studies evaluating PLD plus carboplatin in platinum-sensitive ROC have shown that the regimen is tolerable and active. Conclusion: PLD-carboplatin is a promising chemotherapy combination. Phase III trials will elucidate whether it represents a new standard of care in ovarian cancer.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Keywords

  • Advanced disease
  • Anthracycline
  • Carboplatin
  • Chemotherapy
  • Ovarian cancer
  • Pegylated liposomal doxorubicin
  • Platinum
  • Recurrent

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

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