PELD score and posttransplant outcome in pediatric liver transplantation: A retrospective study of 100 recipients

Christophe Bourdeaux, Tran Thanh Tri, Jérémie Gras, Etienne Sokal, Jean Bernard Otte, Jean De Ville De Goyet, Raymond Reding

Research output: Contribution to journalArticle

Abstract

Background. Pediatric End-stage Liver Disease (PELD) score is proposed as an objective tool to prioritize children awaiting liver transplantation (LT), higher PELD being associated with increased pre-LT mortality. This study investigated whether PELD may also impact on post-LT results. Methods. PELD was retrospectively analyzed in 100 pediatric recipients of a primary LT from living-related (n = 49) or postmortem donors (PMD, n = 51). The main pre-LT diagnosis was biliary atresia (n = 64), hepatic malignancy and fulminant hepatitis cases being excluded. PELD was calculated in all patients at the time of pre-LT assessment. Considering the median delay of 117 days between listing and LT in the PMD subgroup, a second PELD was calculated at the time of LT, allowing the determination of a ΔPELD during the waiting period. PMD grafts were allocated using an allocation system taking into account waiting times as well as medical urgency, operative at EuroTransplant. Results. Overall 5-year actuarial patient and graft survivals were 96% and 91%, respectively. PELD at listing (13.3 ± 9.7) showed a normal statistical distribution. PELD scores at listing and at LT were not found to significantly impact on post-LT outcome (NS). In contrast, higher ΔPELD might be associated with lower posttransplant patient survival (p = 0.094). Conclusions. The results of this retrospective analysis suggest that giving priority to high PELD recipients may not result in worsening post-LT outcome. Accordingly, these data support such "sickest children first" allocation policy, which should contribute to reduce pre-LT mortality without worsening post-LT results and increasing organ waste.

Original languageEnglish
Pages (from-to)1273-1276
Number of pages4
JournalTransplantation
Volume79
Issue number9
DOIs
Publication statusPublished - May 15 2005

Keywords

  • Children
  • Graft allocation policy
  • Liver transplantation
  • Outcome
  • PELD

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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