Pelvic adhesion and gonadotropin-releasing hormone analogue: Effects of triptorelin acetate depot on coagulation and fibrinolytic activities

Maria Antonietta Di Nardo, Maria Laura Annunziata, Massimiliano Ammirabile, Matteo Nicola Dario Di Minno, Anna Lilia Ruocco, Marianna De Falco, Andrea Di Lieto

Research output: Contribution to journalArticlepeer-review

Abstract

The study investigated the impact of gonadotropin-releasing hormone analogue (GnRH-a) on coagulation and fibrinolytic activities and its effectiveness in the prevention of pelvic adhesion after myomectomy. Thirty-two infertile women underwent myomectomy followed by adhesion evaluation surgery with a second-look laparoscopy. Before myomectomy, 15 women were treated with triptorelin acetate for 3 months and 17 received no treatment. Plasminogen activator inhibitor (PAI), thrombin activatable fibrinolysis inhibitor (TAFI), protein C (PC), plasminogen, α2-antiplasmin were determined by enzyme-linked immunosorbent assays and the activity of coagulation factors V and VIII by coagulometric methods. Patients treated with GnRH-a showed significant decrease in PAI, TAFI, factors V, and VIII (P

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalReproductive Sciences
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • coagulation system
  • fibrinolytic system
  • gonadotropin-releasing hormone analogue
  • myomectomy
  • pelvic adhesion

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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