Pelvic recurrences in cervical cancer: Multimodal treatment with sequential intra-arterial chemotherapy and surgery

C. Scarabelli, A. Zarrelli, A. Gallo, E. Campagnutta, C. Visentin, G. Giorda, L. De Marco, F. Sopracordevole, G. De Piero, G. M. Sasso, A. Parin

Research output: Contribution to journalArticlepeer-review

Abstract

Between June 1984 and June 1992, 48 consecutive patients with inoperable recurrent or persistent cervical carcinoma received sequential intra-arterial chemotherapy. Of 48 patients, 20 were pretreated with surgery and radiotherapy, 18 with radiotherapy and 10 with surgery alone. According to the Seldinger's technique, 5 French diameter polyethylene catheters were placed bilaterally in the internal iliac artery. Treatment consisted of a bilateral sequential infusion of polimelfalan 20 mg, doxorubicin 10 mg and cisplatin 20 mg in a 6 hour period via an external infusion pump. The median number of administered cycles was 5 (range 3-7) and the median time for treatment was 27 days. The major toxic effects, according to WHO criteria, were Haematologic 18.7% Grade 3-4, Renal 8.3% Grade 1-2, Gastrointestinal 79.2% Grade 1-2. 8.3% of patients had major local problems causing interruption of treatment: two cases of arterial subocclusion and two cases of femoral aneurysm. 64.6% of patients achieved a clinical response to intra-arterial chemotherapy: 4 (8.3%) had complete re response and 27 (56.2%) had partial response. All 31 responding patients underwent pelvic surgery. Of these, 10 (32.3%) underwent radical surgery and 21 (67.7%) palliative surgery. Two (50%) of 4 patients achieving clinical complete response had also pathological complete response; The median follow-up was 35 months (range 14-110). The survival rate was significantly (p

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalRegional Cancer Treatment
Volume7
Issue number1
Publication statusPublished - 1994

Keywords

  • Cervix neoplasms
  • Intra-arterial chemotherapy
  • Neoplasm recurrence local

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

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