Pelvic ultrasound, serum CA125 assay, CA19.9 assay and serum CA72.4 assay in the differential diagnosis of ovarian masses

A. Gadducci, P. Capriello, M. Ferdeghini, A. Madrigali, A. Puccetti, C. Annicchiarico, C. Prontera, R. Bianchi, P. Fioretti

Research output: Contribution to journalArticlepeer-review

Abstract

Pelvic ultrasound, serum CA125 assay, serum CA19.9 assay and serum CA72.4 assay were preoperatively performed in 204 patients with ovarian masses undergoing laparotomy. All ultrasonogram examinations were scored using a personal morphological echostructural evaluation system. Each mass was graded between 0 and 16. Ultrasound score ≥8, serum CA125 levels ≥81 U/ml, CA19.9 ≥40 U/ml and serum CA72.4 levels ≥3.2 U/ml were respectively found in 51 (77.3%), 52 (78.8%), 22 (33.3%) and 48 (72.7%) of the 66 patients with ovarian carcinoma and in 10 (7.2%), 8 (5.8%), 26(18.8%) and 13 (9.4%) of the 138 patients with benign ovarian pathology. The combined evaluation of ultrasound, CA125 assay and CA19.9 assay had significantly higher sensitivity (94.2% vs 80.8% p = 0.0361) but not significantly lower specificity (81.5% vs 88.9% , p = NS) with respect to ultrasound alone in postmenopausal patients; in the same group of patients the association of ultrasound, CA125 assay and CA72.4 assay had significantly increased sensitivity (94.2% vs 80.8% , p = 0.0361) but not significantly decreased specificity (74.1% vs 88.9% , p = NS) when compared to ultrasound alone. In conclusion, the serum assay of CA125 and CA19.9 or CA72.4 seemed to improve the reliability of ultrasound in the differential diagnosis of ovarian masses in post-menopausal patients.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalCancer Journal (United States)
Volume4
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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