Pemetrexed in heavily pretreated non-small-cell lung cancer patients: Case report and review of the literature

Alfredo Tartarone

Research output: Contribution to journalArticlepeer-review

Abstract

To date, there is no standard treatment for patients with metastatic non-small-cell lung cancer after multiple previous lines of chemotherapy. Pemetrexed in combination with cisplatin or as a single agent demonstrated significant activity in patients with nonsquamous non-small-cell lung cancer with a good toxicity profile. In this article, we present a case of pulmonary adenocarcinoma treated with pemetrexed after five lines of treatment, including the cytotoxic agents cisplatin plus vinorelbine, docetaxel, gemcitabine and the tyrosine kinase inhibitor erlotinib. We also review the role of pemetrexed in this setting of patients.

Original languageEnglish
Pages (from-to)1937-1940
Number of pages4
JournalFuture Oncology
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • clinical decision-making
  • nonsquamous non-small-cell lung cancer
  • pemetrexed
  • salvage chemotherapy
  • thymidylate synthase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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