Penetration of roxithromycin into bronchial secretions

A. Boccazzi, M. Langerb

Research output: Contribution to journalArticlepeer-review

Abstract

The penetration of an antibacterial agent into the bronchial secretions is a crucial factor in determining its clinical efficacy in the treatment of bacterial respiratory infections. Roxithromycin is a novel macrolide compound active against the most frequent respiratory pathogens. Following administration of 150 mg p.o., we observed a prompt penetration of the compound into bronchial secretions of critically ill patients. Elevated concentrations above the MICs of the commonest susceptible pathogens are reached and maintained until the next administration.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalChemotherapy
Volume37
Issue number5
DOIs
Publication statusPublished - 1991

Keywords

  • Bronchial secretions
  • Pharmacokinetics
  • Roxithromycin

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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