Penicillin CSF levels following intravenous therapy in syphilitic patients

L. Faggi, A. Citterio, G. M. Frigo, E. Perucca, S. Lecchini, A. Giannetti

Research output: Contribution to journalArticlepeer-review


Serum and CSF levels of penicillin have been determined in 13 syphilitic patients treated with relatively high doses of penicillin G by the intravenous route. Wide individual variability in the CSF/serum concentration ratio was observed. In all patients the concentration of the antibiotic in the CSF was equal to or greater than 0.03 IU/ml., which is considered to be the minimal therapeutic concentration. The potential clinical usefulness of different therapeutic regimens in the treatment of neurosyphilis is discussed.

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - Dec 1983


  • CSF levels
  • neurosyphilis
  • Penicillin
  • syphilis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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