Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion

Saverio Dragoni, Tommaso Gori, Monica Lisi, Giuseppe Di Stolfo, Andrea Pautz, Hartmut Kleinert, John D. Parker

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

Original languageEnglish
Pages (from-to)1955-1959
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2007

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isosorbide-5-mononitrate
Nitroglycerin
Vasodilation
Reperfusion
Ischemia
Ischemic Preconditioning
Group Psychotherapy
Nitrates
Endothelium
Healthy Volunteers

Keywords

  • Ischemia reperfusion injury
  • Nitric oxide
  • Organic nitrates
  • Oxygen-derived free radicals
  • Preconditioning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. / Dragoni, Saverio; Gori, Tommaso; Lisi, Monica; Di Stolfo, Giuseppe; Pautz, Andrea; Kleinert, Hartmut; Parker, John D.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 9, 09.2007, p. 1955-1959.

Research output: Contribution to journalArticle

Dragoni, Saverio ; Gori, Tommaso ; Lisi, Monica ; Di Stolfo, Giuseppe ; Pautz, Andrea ; Kleinert, Hartmut ; Parker, John D. / Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 ; Vol. 27, No. 9. pp. 1955-1959.
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AU - Dragoni, Saverio

AU - Gori, Tommaso

AU - Lisi, Monica

AU - Di Stolfo, Giuseppe

AU - Pautz, Andrea

AU - Kleinert, Hartmut

AU - Parker, John D.

PY - 2007/9

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N2 - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

AB - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

KW - Ischemia reperfusion injury

KW - Nitric oxide

KW - Organic nitrates

KW - Oxygen-derived free radicals

KW - Preconditioning

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