Abstract
BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P
| Original language | English |
|---|---|
| Pages (from-to) | 1955-1959 |
| Number of pages | 5 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 27 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2007 |
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Keywords
- Ischemia reperfusion injury
- Nitric oxide
- Organic nitrates
- Oxygen-derived free radicals
- Preconditioning
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. / Dragoni, Saverio; Gori, Tommaso; Lisi, Monica; Di Stolfo, Giuseppe; Pautz, Andrea; Kleinert, Hartmut; Parker, John D.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 9, 09.2007, p. 1955-1959.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion
AU - Dragoni, Saverio
AU - Gori, Tommaso
AU - Lisi, Monica
AU - Di Stolfo, Giuseppe
AU - Pautz, Andrea
AU - Kleinert, Hartmut
AU - Parker, John D.
PY - 2007/9
Y1 - 2007/9
N2 - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P
AB - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P
KW - Ischemia reperfusion injury
KW - Nitric oxide
KW - Organic nitrates
KW - Oxygen-derived free radicals
KW - Preconditioning
UR - http://www.scopus.com/inward/record.url?scp=34548160261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548160261&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.107.149278
DO - 10.1161/ATVBAHA.107.149278
M3 - Article
VL - 27
SP - 1955
EP - 1959
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 9
ER -