Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion

Saverio Dragoni; Tommaso Gori; Monica Lisi; Giuseppe Di Stolfo; Andrea Pautz; Hartmut Kleinert; John D. Parker

doi:10.1161/ATVBAHA.107.149278

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion

Saverio Dragoni, Tommaso Gori, Monica Lisi, Giuseppe Di Stolfo, Andrea Pautz, Hartmut Kleinert, John D. Parker

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article

Abstract

BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

Original language	English
Pages (from-to)	1955-1959
Number of pages	5
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	27
Issue number	9
DOIs	https://doi.org/10.1161/ATVBAHA.107.149278
Publication status	Published - Sep 2007

Keywords

Ischemia reperfusion injury
Nitric oxide
Organic nitrates
Oxygen-derived free radicals
Preconditioning

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1161/ATVBAHA.107.149278

Fingerprint Dive into the research topics of 'Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion'. Together they form a unique fingerprint.

Cite this

Dragoni, S., Gori, T., Lisi, M., Di Stolfo, G., Pautz, A., Kleinert, H., & Parker, J. D. (2007). Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(9), 1955-1959. https://doi.org/10.1161/ATVBAHA.107.149278

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. / Dragoni, Saverio; Gori, Tommaso; Lisi, Monica; Di Stolfo, Giuseppe; Pautz, Andrea; Kleinert, Hartmut; Parker, John D.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 9, 09.2007, p. 1955-1959.

Research output: Contribution to journal › Article

@article{cf6e9d593ce046bf9f41678d9110b3c8,

title = "Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion",

abstract = "BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P",

keywords = "Ischemia reperfusion injury, Nitric oxide, Organic nitrates, Oxygen-derived free radicals, Preconditioning",

author = "Saverio Dragoni and Tommaso Gori and Monica Lisi and {Di Stolfo}, Giuseppe and Andrea Pautz and Hartmut Kleinert and Parker, {John D.}",

year = "2007",

month = sep,

doi = "10.1161/ATVBAHA.107.149278",

language = "English",

volume = "27",

pages = "1955--1959",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion

AU - Dragoni, Saverio

AU - Gori, Tommaso

AU - Lisi, Monica

AU - Di Stolfo, Giuseppe

AU - Pautz, Andrea

AU - Kleinert, Hartmut

AU - Parker, John D.

PY - 2007/9

Y1 - 2007/9

N2 - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

AB - BACKGROUND - Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS - In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteers received no therapy (n=10), transdermal GTN 1.2 mg for 2 hours (n=9), PETN 80 mg (n=9), or ISMN 40 mg (n=9). Twenty-four hours later, endothelium-dependent flow-mediated vasodilation (FMD) was measured before and after local exposure to ischemia and reperfusion (IR). In the no therapy group, IR blunted FMD (FMD after IR: 1.9±0.6%, P

KW - Ischemia reperfusion injury

KW - Nitric oxide

KW - Organic nitrates

KW - Oxygen-derived free radicals

KW - Preconditioning

UR - http://www.scopus.com/inward/record.url?scp=34548160261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548160261&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.107.149278

DO - 10.1161/ATVBAHA.107.149278

M3 - Article

C2 - 17641250

AN - SCOPUS:34548160261

VL - 27

SP - 1955

EP - 1959

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 9

ER -