Pentalogy of Cantrell: Embryofetoscopic Diagnosis

Attilio Di Spiezio Sardo, Dario Paladini, Brunella Zizolfi, Marialuigia Spinelli, Carmine Nappi

Research output: Contribution to journalArticlepeer-review


Embryofetoscopy is an endoscopic technique that permits a direct visualization and morphologic study of embryos during the first and early second trimester. We report the early prenatal diagnosis of a case of Pentalogy of Cantrell combining data obtained by 2-dimensional and 3-dimensional ultrasonography and embryofetoscopy. Morphologic examination focused on a large omphalocele protruding from the anterior abdominal wall as an oval pulsating mass, measuring approximately 3 cm. The visualization of an omphalocele with ectopia cordis without other malformations confirmed the diagnosis of Pentalogy of Cantrell (class III). Currently, embryofetoscopy allows direct visualization of the embryo in vivo, enabling accurate diagnosis of developmental defects and yielding additional insights into developmental disorders in the embryo.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
JournalJournal of Minimally Invasive Gynecology
Issue number2
Publication statusPublished - Mar 2013


  • Embryofetoscopy
  • Pentalogy of Cantrell
  • Ultrasonography

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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