Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia

Pier Giorgio Mori, Riccardo Haupt, Giusy Fugazza, Mario Sessarego, Anna Corcione, Paolo Strigini, Raffaele Sansone

Research output: Contribution to journalArticle

Abstract

We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.

Original languageEnglish
Pages (from-to)70-72
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume63
Issue number1
DOIs
Publication statusPublished - Oct 1 1992

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Diamond-Blackfan Anemia
Karyotype
Leukemia
Clonal Evolution
Chromosomes, Human, Pair 21
Down Syndrome
Cytogenetics
Lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia. / Mori, Pier Giorgio; Haupt, Riccardo; Fugazza, Giusy; Sessarego, Mario; Corcione, Anna; Strigini, Paolo; Sansone, Raffaele.

In: Cancer Genetics and Cytogenetics, Vol. 63, No. 1, 01.10.1992, p. 70-72.

Research output: Contribution to journalArticle

Mori, Pier Giorgio ; Haupt, Riccardo ; Fugazza, Giusy ; Sessarego, Mario ; Corcione, Anna ; Strigini, Paolo ; Sansone, Raffaele. / Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia. In: Cancer Genetics and Cytogenetics. 1992 ; Vol. 63, No. 1. pp. 70-72.
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