Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia

Pier Giorgio Mori; Riccardo Haupt; Giusy Fugazza; Mario Sessarego; Anna Corcione; Paolo Strigini; Raffaele Sansone

doi:10.1016/0165-4608(92)90067-I

Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia

Pier Giorgio Mori, Riccardo Haupt, Giusy Fugazza, Mario Sessarego, Anna Corcione, Paolo Strigini, Raffaele Sansone

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.

Original language	English
Pages (from-to)	70-72
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(92)90067-I
Publication status	Published - Oct 1 1992

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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title = "Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia",

abstract = "We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.",

author = "Mori, {Pier Giorgio} and Riccardo Haupt and Giusy Fugazza and Mario Sessarego and Anna Corcione and Paolo Strigini and Raffaele Sansone",

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AU - Mori, Pier Giorgio

AU - Haupt, Riccardo

AU - Fugazza, Giusy

AU - Sessarego, Mario

AU - Corcione, Anna

AU - Strigini, Paolo

AU - Sansone, Raffaele

PY - 1992/10/1

Y1 - 1992/10/1

N2 - We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.

AB - We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.

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