Abstract
We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.
| Original language | English |
|---|---|
| Pages (from-to) | 70-72 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1 1992 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia. / Mori, Pier Giorgio; Haupt, Riccardo; Fugazza, Giusy; Sessarego, Mario; Corcione, Anna; Strigini, Paolo; Sansone, Raffaele.
In: Cancer Genetics and Cytogenetics, Vol. 63, No. 1, 01.10.1992, p. 70-72.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Pentasomy 21 in leukemia complicating Diamond-Blackfan anemia
AU - Mori, Pier Giorgio
AU - Haupt, Riccardo
AU - Fugazza, Giusy
AU - Sessarego, Mario
AU - Corcione, Anna
AU - Strigini, Paolo
AU - Sansone, Raffaele
PY - 1992/10/1
Y1 - 1992/10/1
N2 - We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.
AB - We present the cytogenetic pattern of a leukemic infant with Diamond-Blackfan anemia (DBA). The karyotype was characterized by clonal evolution involving consecutive gains of chromosome 21 up to pentasomy. No chromosomal changes were present in normal lymphocytes. Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.
UR - http://www.scopus.com/inward/record.url?scp=0026476102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026476102&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(92)90067-I
DO - 10.1016/0165-4608(92)90067-I
M3 - Article
C2 - 1423230
AN - SCOPUS:0026476102
VL - 63
SP - 70
EP - 72
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -