Abstract
Subhypnotic doses (10 and 20 mg/kg) of pentobarbital significantly elevated locomotor activity measured for 30 min in CD-1 mice. The hyperactivity was also observed in mice recovering from pentobarbital-induced (50 mg/kg) sleep (measurements starting 15 min after recovery of righting reflex). Naloxone in doses up to 4 mg/kg did not affect significantly the pentobarbital-induced hyperactivity in any experiment; a dose of 8 mg/kg only partially attenuated the hyperactivity induced by a dose of 20 mg/kg of pentobarbital, but did not affect significantly either the stimulatory effect of a low subhypnotic dose (10 mg/kg) or the posthypnotic hyperactivity. This suggests a negligible involvement of opioid mechanism in the hyperactivity induced by pentobarbital.
Original language | English |
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Pages (from-to) | 927-929 |
Number of pages | 3 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 33 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1989 |
Keywords
- Locomotor activity
- Mice
- Naloxone
- Pentobarbital
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology