Pentobarbital-induced hyperactivity in mice: Negligible role of opioid mechanisms

Jerzy Vetulani, Flaminia Pavone, Mario Battaglia, Mario Sansone

Research output: Contribution to journalArticlepeer-review

Abstract

Subhypnotic doses (10 and 20 mg/kg) of pentobarbital significantly elevated locomotor activity measured for 30 min in CD-1 mice. The hyperactivity was also observed in mice recovering from pentobarbital-induced (50 mg/kg) sleep (measurements starting 15 min after recovery of righting reflex). Naloxone in doses up to 4 mg/kg did not affect significantly the pentobarbital-induced hyperactivity in any experiment; a dose of 8 mg/kg only partially attenuated the hyperactivity induced by a dose of 20 mg/kg of pentobarbital, but did not affect significantly either the stimulatory effect of a low subhypnotic dose (10 mg/kg) or the posthypnotic hyperactivity. This suggests a negligible involvement of opioid mechanism in the hyperactivity induced by pentobarbital.

Original languageEnglish
Pages (from-to)927-929
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume33
Issue number4
DOIs
Publication statusPublished - 1989

Keywords

  • Locomotor activity
  • Mice
  • Naloxone
  • Pentobarbital

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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