Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons

Mario Clerici, Stefania Piconi, Claudia Balotta, Daria Trabattoni, Amedeo Capetti, Maria Luisa Fusi, Stefania Ruzzante, Renato Longhi, Maria Chiara Colombo, Mauro Moroni, Francesco Milazzo

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Abstract

The effects of pentoxifylline on immunologic and virologic parameters were evaluated in 10 human immunodeficiency virus-infected patients not receiving antiretroviral treatment. Patients were asymptomatic, had 300-500 CD4 cells/μL, and received pentoxifylline (1200 rag/day orally) for 4 months. Peripheral blood mononuclear cells were tested before and at five time points during therapy. A transient increase in CD4 cells was observed in 8 of 9 patients, and CD8 cells increased in 7 of 9 patients. These increases were negatively correlated with susceptibility to in vitro mitogen-stimulated apoptotic cell death. Pentoxifylline had a temporary effect on mitogen- stimulated cytokine production; thus, interferon-γ, interleukin (IL)-2, tumor necrosis factor-α, and lymphotoxin increased more than IL-10. Pentoxifylline also potentiated antigen-stimulated IL-2 production and proliferation in 8 of 9 patients and induced significant but transient decreases in plasma viremia in 7 of 9 patients. These preliminary findings suggest that pentoxifylline in vivo has an interesting but temporary influence on both immunologic and virologic parameters.

Original languageEnglish
Pages (from-to)1210-1215
Number of pages6
JournalJournal of Infectious Diseases
Volume175
Issue number5
Publication statusPublished - 1997

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Pentoxifylline
Viremia
Cellular Immunity
HIV
Mitogens
Interleukin-2
Lymphotoxin-alpha
Interleukin-10
Interferons
Blood Cells
Cell Death
Tumor Necrosis Factor-alpha
Cytokines
Antigens
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons. / Clerici, Mario; Piconi, Stefania; Balotta, Claudia; Trabattoni, Daria; Capetti, Amedeo; Fusi, Maria Luisa; Ruzzante, Stefania; Longhi, Renato; Colombo, Maria Chiara; Moroni, Mauro; Milazzo, Francesco.

In: Journal of Infectious Diseases, Vol. 175, No. 5, 1997, p. 1210-1215.

Research output: Contribution to journalArticle

Clerici, M, Piconi, S, Balotta, C, Trabattoni, D, Capetti, A, Fusi, ML, Ruzzante, S, Longhi, R, Colombo, MC, Moroni, M & Milazzo, F 1997, 'Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons', Journal of Infectious Diseases, vol. 175, no. 5, pp. 1210-1215.
Clerici, Mario ; Piconi, Stefania ; Balotta, Claudia ; Trabattoni, Daria ; Capetti, Amedeo ; Fusi, Maria Luisa ; Ruzzante, Stefania ; Longhi, Renato ; Colombo, Maria Chiara ; Moroni, Mauro ; Milazzo, Francesco. / Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 5. pp. 1210-1215.
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