Pentraxin 3 in acute respiratory distress syndrome: An early marker of severity

Tommaso Mauri, Andrea Coppadoro, Giacomo Bellani, Michela Bombino, Nicolo' Patroniti, Giuseppe Peri, Alberto Mantovani, Antonio Pesenti

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Pentraxin 3 is a fluid phase receptor involved in innate immunity. It belongs to the Pentraxins family, as C-reactive protein does. Pentraxin 3 is produced by a variety of tissue cells, whereas only the liver produces C-reactive protein. Pentraxin 3 plays a unique role in the regulation of inflammation. Acute lung injury and acute respiratory distress syndrome are characterized by an important inflammatory reaction. We investigated the role of pentraxin 3 as a marker of severity and outcome predictor of acute lung injury and acute respiratory distress syndrome. DESIGN: We measured circulating pentraxin 3 and C-reactive protein levels within 24 hrs from intubation (day 1), after 24 hrs from the first sample, then every 3 days for the first month and then once a week, until discharge from the intensive care unit. Pentraxin 3 was also measured in bronchoalveolar lavages, performed when clinically indicated. SETTING: One university medical center general intensive care unit. PATIENTS: The study included 21 patients affected by acute lung injury and acute respiratory distress syndrome (1994 Consensus Conference criteria). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Pentraxin 3 plasma levels were high with a peak on the first day (median 71.05 ng/mL, interquartile range 52.37-117.38 ng/mL, normal values

Original languageEnglish
Pages (from-to)2302-2308
Number of pages7
JournalCritical Care Medicine
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Acute respiratory distress syndrome
  • Inflammation
  • Marker
  • Multiple organ failure
  • Outcome
  • Pentraxin 3
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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