Pentraxin-3 predicts functional recovery and 1-year major adverse cardiovascular events after rehabilitation of cardiac surgery patients

Maurizio Ferratini, Vittorino Ripamonti, Serge Masson, Paola Grati, Vittorio Racca, Ivan Cuccovillo, Elena Raimondi, Soccorso Capomolla, Claudio Macchi, Paolo Coruzzi, Tarcisio Vago, Maria Calvo, Alberto Mantovani, Roberto Latini

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation. METHODS: This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables. RESULTS: The patients (69.5% men, mean age of 67 ± 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG). Exercise capacity improved during rehabilitation (6MWT distance from 279 ± 95 to 386 ± 91 m; P <.0001); concentrations of most biomarkers decreased (hsCRP: 79% [P <.0001]; hs-cTnT: 57% [P <.0001]; UACR: 36% [P = .05]). Among the tested markers, PTX3 showed the closest association with 6MWT distance (P = .01) and was the only predictor of MACE, also in the subgroup of CABG patients (OR [95% CI] = 1.14 [1.03-1.27]; P = .015). CONCLUSION: PTX3, a marker of vascular inflammation and cardiovascular damage, is a predictor of short-term functional recovery and 1-year MACE in patients undergoing rehabilitation after cardiac surgery, regardless of clinical and instrumental parameters.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Thoracic Surgery
Rehabilitation
Troponin T
Biomarkers
Coronary Artery Bypass
C-Reactive Protein
Blood Vessels
Albumins
Heart Failure
Exercise
Troponin C
Inflammation
Myoglobin
Brain Natriuretic Peptide
Creatine Kinase
Protein Kinases
Multicenter Studies
Inpatients
Myocardial Infarction
PTX3 protein

Keywords

  • biomarkers
  • cardiac rehabilitation
  • cardiac surgery
  • pentraxin-3

ASJC Scopus subject areas

  • Rehabilitation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Pentraxin-3 predicts functional recovery and 1-year major adverse cardiovascular events after rehabilitation of cardiac surgery patients. / Ferratini, Maurizio; Ripamonti, Vittorino; Masson, Serge; Grati, Paola; Racca, Vittorio; Cuccovillo, Ivan; Raimondi, Elena; Capomolla, Soccorso; Macchi, Claudio; Coruzzi, Paolo; Vago, Tarcisio; Calvo, Maria; Mantovani, Alberto; Latini, Roberto.

In: Journal of Cardiopulmonary Rehabilitation and Prevention, Vol. 32, No. 1, 01.2012, p. 17-24.

Research output: Contribution to journalArticle

Ferratini, Maurizio ; Ripamonti, Vittorino ; Masson, Serge ; Grati, Paola ; Racca, Vittorio ; Cuccovillo, Ivan ; Raimondi, Elena ; Capomolla, Soccorso ; Macchi, Claudio ; Coruzzi, Paolo ; Vago, Tarcisio ; Calvo, Maria ; Mantovani, Alberto ; Latini, Roberto. / Pentraxin-3 predicts functional recovery and 1-year major adverse cardiovascular events after rehabilitation of cardiac surgery patients. In: Journal of Cardiopulmonary Rehabilitation and Prevention. 2012 ; Vol. 32, No. 1. pp. 17-24.
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AU - Ferratini, Maurizio

AU - Ripamonti, Vittorino

AU - Masson, Serge

AU - Grati, Paola

AU - Racca, Vittorio

AU - Cuccovillo, Ivan

AU - Raimondi, Elena

AU - Capomolla, Soccorso

AU - Macchi, Claudio

AU - Coruzzi, Paolo

AU - Vago, Tarcisio

AU - Calvo, Maria

AU - Mantovani, Alberto

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N2 - BACKGROUND: Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation. METHODS: This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables. RESULTS: The patients (69.5% men, mean age of 67 ± 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG). Exercise capacity improved during rehabilitation (6MWT distance from 279 ± 95 to 386 ± 91 m; P <.0001); concentrations of most biomarkers decreased (hsCRP: 79% [P <.0001]; hs-cTnT: 57% [P <.0001]; UACR: 36% [P = .05]). Among the tested markers, PTX3 showed the closest association with 6MWT distance (P = .01) and was the only predictor of MACE, also in the subgroup of CABG patients (OR [95% CI] = 1.14 [1.03-1.27]; P = .015). CONCLUSION: PTX3, a marker of vascular inflammation and cardiovascular damage, is a predictor of short-term functional recovery and 1-year MACE in patients undergoing rehabilitation after cardiac surgery, regardless of clinical and instrumental parameters.

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