Pentraxins and atherosclerosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pentraxins are a family of evolutionarily conserved multifunctional patternrecognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells and endothelial cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. Structural analysis and gene-modified mice have provided a new level of understanding of the role of pentraxins in immunity, inflammation and homeostasis. Unlike the classic short pentraxins CRP and SAP, whose sequence and regulation have diverged between mouse and man, PTX3 is highly conserved in man and mouse. Thus, results obtained using genetic approaches in the mouse are likely to be informative for the function of PTX3 in man, whereas extrapolation from animals to man is more difficult for CRP and SAP.

Original languageEnglish
Title of host publicationInflammation and Atherosclerosis
PublisherSpringer-Verlag Wien
Pages219-237
Number of pages19
ISBN (Print)9783709103388, 3709103371, 9783709103371
DOIs
Publication statusPublished - Apr 1 2014

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Barbati, E., Bottazzi, B., Catapano, A. L., Garlanda, C., Latini, R., Mantovani, A., Norata, G. D., & Valentino, S. (2014). Pentraxins and atherosclerosis. In Inflammation and Atherosclerosis (pp. 219-237). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0338-8_11