Pentraxins as a key component of innate immunity

Barbara Bottazzi, Cecilia Garlanda, Giovanni Salvatori, Pascale Jeannin, Angelo Manfredi, Alberto Mantovani

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalCurrent Opinion in Immunology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2006

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Innate Immunity
C-Reactive Protein
Inflammation
PTX3 protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pentraxins as a key component of innate immunity. / Bottazzi, Barbara; Garlanda, Cecilia; Salvatori, Giovanni; Jeannin, Pascale; Manfredi, Angelo; Mantovani, Alberto.

In: Current Opinion in Immunology, Vol. 18, No. 1, 02.2006, p. 10-15.

Research output: Contribution to journalArticle

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