Abstract
Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 10-15 |
| Number of pages | 6 |
| Journal | Current Opinion in Immunology |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2006 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Pentraxins as a key component of innate immunity. / Bottazzi, Barbara; Garlanda, Cecilia; Salvatori, Giovanni; Jeannin, Pascale; Manfredi, Angelo; Mantovani, Alberto.
In: Current Opinion in Immunology, Vol. 18, No. 1, 02.2006, p. 10-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pentraxins as a key component of innate immunity
AU - Bottazzi, Barbara
AU - Garlanda, Cecilia
AU - Salvatori, Giovanni
AU - Jeannin, Pascale
AU - Manfredi, Angelo
AU - Mantovani, Alberto
PY - 2006/2
Y1 - 2006/2
N2 - Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
AB - Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
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UR - http://www.scopus.com/inward/citedby.url?scp=30044448336&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2005.11.009
DO - 10.1016/j.coi.2005.11.009
M3 - Article
C2 - 16343883
AN - SCOPUS:30044448336
VL - 18
SP - 10
EP - 15
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -