Pentraxins as a key component of innate immunity

Barbara Bottazzi; Cecilia Garlanda; Giovanni Salvatori; Pascale Jeannin; Angelo Manfredi; Alberto Mantovani

doi:10.1016/j.coi.2005.11.009

Pentraxins as a key component of innate immunity

Barbara Bottazzi, Cecilia Garlanda, Giovanni Salvatori, Pascale Jeannin, Angelo Manfredi, Alberto Mantovani

Research output: Contribution to journal › Article › peer-review

Abstract

Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Current Opinion in Immunology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.coi.2005.11.009
Publication status	Published - Feb 2006

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.coi.2005.11.009

Fingerprint Dive into the research topics of 'Pentraxins as a key component of innate immunity'. Together they form a unique fingerprint.

Cite this

@article{84b1f5e4138b42899f762cf382c65c2a,

title = "Pentraxins as a key component of innate immunity",

abstract = "Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.",

author = "Barbara Bottazzi and Cecilia Garlanda and Giovanni Salvatori and Pascale Jeannin and Angelo Manfredi and Alberto Mantovani",

year = "2006",

month = feb,

doi = "10.1016/j.coi.2005.11.009",

language = "English",

volume = "18",

pages = "10--15",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Pentraxins as a key component of innate immunity

AU - Bottazzi, Barbara

AU - Garlanda, Cecilia

AU - Salvatori, Giovanni

AU - Jeannin, Pascale

AU - Manfredi, Angelo

AU - Mantovani, Alberto

PY - 2006/2

Y1 - 2006/2

N2 - Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

AB - Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

UR - http://www.scopus.com/inward/record.url?scp=30044448336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30044448336&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2005.11.009

DO - 10.1016/j.coi.2005.11.009

M3 - Article

C2 - 16343883

AN - SCOPUS:30044448336

VL - 18

SP - 10

EP - 15

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 1

ER -