Pentraxins in innate immunity and inflammation

Cecilia Garlanda, Barbara Bottazzi, Giovanni Salvatori, Rita De Santis, Alessia Cotena, Livija Deban, Viriginia Maina, Federica Moalli, Andrea Doni, Tania Veliz-Rodriguez, Alberto Mantovani

Research output: Chapter in Book/Report/Conference proceedingChapter


C-reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, the prototype of which is PTX3, are expressed in a variety of tissues. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to TLR engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, hence playing a non-redundant role in resistance against selected pathogens, in particular in the lung. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition and female fertility.

Original languageEnglish
Title of host publicationInnate Immunity to Pulmonary Infection
Number of pages12
ISBN (Print)9780470035399, 9780470015971
Publication statusPublished - Oct 7 2008


  • Apoptotic cells
  • Innate resistance
  • Opsonization
  • PTX3

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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