Pentraxins in innate immunity and inflammation

Cecilia Garlanda, Barbara Bottazzi, Giovanni Salvatori, Rita De Santis, Alessia Cotena, Livija Deban, Viriginia Maina, Federica Moalli, Andrea Doni, Tania Veliz-Rodriguez, Alberto Mantovani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

C-reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, the prototype of which is PTX3, are expressed in a variety of tissues. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to TLR engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, hence playing a non-redundant role in resistance against selected pathogens, in particular in the lung. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition and female fertility.

Original languageEnglish
Title of host publicationInnate Immunity to Pulmonary Infection
Publisherwiley
Pages80-91
Number of pages12
ISBN (Print)9780470035399, 9780470015971
DOIs
Publication statusPublished - Oct 7 2008

Keywords

  • Apoptotic cells
  • Innate resistance
  • Opsonization
  • PTX3

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Garlanda, C., Bottazzi, B., Salvatori, G., Santis, R. D., Cotena, A., Deban, L., Maina, V., Moalli, F., Doni, A., Veliz-Rodriguez, T., & Mantovani, A. (2008). Pentraxins in innate immunity and inflammation. In Innate Immunity to Pulmonary Infection (pp. 80-91). wiley. https://doi.org/10.1002/9780470035399.ch7