TY - JOUR
T1 - People living with undiagnosed HIV infection and a low CD4 count
T2 - Estimates from surveillance data, Italy, 2012 to 2014
AU - The regional representatives of the National HIV Surveillance System
AU - Regine, Vincenza
AU - Dorrucci, Maria
AU - Pezzotti, Patrizio
AU - Mammone, Alessia
AU - Quinten, Chantal
AU - Pharris, Anastasia
AU - Suligoi, Barbara
AU - Di Giacomo, Manuela
AU - Faggioni, Viviana
AU - Scancella, Luigi
AU - Locuratolo, Francesco
AU - Cauzillo, Gabriella
AU - Mignuoli, Anna Domenica
AU - Chirico, Daniele Giuseppe
AU - Borgia, Guglielmo
AU - Massimiliani, Erika
AU - Gallo, Tolinda
AU - Braida, Cinzia
AU - Puro, Vincenzo
AU - Scognamiglio, Paola
AU - Mammone, Alessia
AU - Lai, Piero Luigi
AU - Gramegna, Maria
AU - Coppola, Liliana
AU - Piatti, Alessandra
AU - Rosa, Annamaria
AU - Cereda, Danilo
AU - Filippetti, Fabio
AU - Prozzo, Alessandra
AU - Pasqualini, Chiara
AU - Mian, Peter
AU - Moling, Oswald
AU - Pagani, Leonardo
AU - Lanzafame, Paolo
AU - Collini, Lucia
AU - Bassetti, Danila
AU - Chironna, Maria
AU - Palmas, Maria Antonietta
AU - Dardanoni, Gabriella
AU - Voller, Fabio
AU - Puglia, Monia
AU - Pecori, Lucia
AU - Tosti, Anna
AU - Papili, Rita
AU - Ruffier, Mauro
AU - Verardo, Marina Giulia
AU - Echarlod, Elisa Francesca
AU - Amoroso, Saveria
AU - Russo, Francesca
AU - Da Re, Filippo
PY - 2018/4/12
Y1 - 2018/4/12
N2 - Background and aims: Late HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 –2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954–8,043) from 2012–2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3–14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3–450.2) per 100,000 MSM, 8.3 (95% CI: 4.9–13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4–5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9–45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.
AB - Background and aims: Late HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 –2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954–8,043) from 2012–2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3–14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3–450.2) per 100,000 MSM, 8.3 (95% CI: 4.9–13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4–5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9–45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.
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U2 - 10.2807/1560-7917.ES.2018.23.15.17-00240
DO - 10.2807/1560-7917.ES.2018.23.15.17-00240
M3 - Article
AN - SCOPUS:85045995786
VL - 23
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1560-7917
IS - 15
M1 - 17-00240
ER -