People living with undiagnosed HIV infection and a low CD4 count

estimates from surveillance data, Italy, 2012 to 2014

Vincenza Regine, Maria Dorrucci, Patrizio Pezzotti, Alessia Mammone, Chantal Quinten, Anastasia Pharris, Barbara Suligoi, The Regional Representatives Of The National Hiv Surveillance System

Research output: Contribution to journalArticle

Abstract

Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954-8,043) from 2012-2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3-14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3-450.2) per 100,000 MSM, 8.3 (95% CI: 4.9-13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4-5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9-45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.

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CD4 Lymphocyte Count
Italy
HIV Infections
HIV
Heterosexuality
Confidence Intervals
Centers for Disease Control and Prevention (U.S.)
Health Care Costs
Morbidity
Mortality

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@article{537d68986942460e9ef09ba3e263f954,
title = "People living with undiagnosed HIV infection and a low CD4 count: estimates from surveillance data, Italy, 2012 to 2014",
abstract = "Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95{\%} confidence interval (CI): 4,954-8,043) from 2012-2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8{\%}), a third acquired HIV through sex between men (MSM) (35.0{\%}), and heterosexual transmission (33.4{\%}), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95{\%} CI: 9.3-14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95{\%} CI: 173.3-450.2) per 100,000 MSM, 8.3 (95{\%} CI: 4.9-13.6) per 100,000 heterosexual men, and 3.0 (95{\%} CI: 1.4-5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1{\%}; 95{\%} CI: 16.9-45.2{\%}). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.",
author = "Vincenza Regine and Maria Dorrucci and Patrizio Pezzotti and Alessia Mammone and Chantal Quinten and Anastasia Pharris and Barbara Suligoi and {The Regional Representatives Of The National Hiv Surveillance System}",
year = "2018",
month = "4",
doi = "10.2807/1560-7917.ES.2018.23.15.17-00240",
language = "English",
volume = "23",
journal = "Eurosurveillance",
issn = "1560-7917",
publisher = "European Centre for Disease Prevention and Control (ECDC)",
number = "15",

}

TY - JOUR

T1 - People living with undiagnosed HIV infection and a low CD4 count

T2 - estimates from surveillance data, Italy, 2012 to 2014

AU - Regine, Vincenza

AU - Dorrucci, Maria

AU - Pezzotti, Patrizio

AU - Mammone, Alessia

AU - Quinten, Chantal

AU - Pharris, Anastasia

AU - Suligoi, Barbara

AU - The Regional Representatives Of The National Hiv Surveillance System, null

PY - 2018/4

Y1 - 2018/4

N2 - Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954-8,043) from 2012-2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3-14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3-450.2) per 100,000 MSM, 8.3 (95% CI: 4.9-13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4-5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9-45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.

AB - Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954-8,043) from 2012-2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3-14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3-450.2) per 100,000 MSM, 8.3 (95% CI: 4.9-13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4-5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9-45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.

U2 - 10.2807/1560-7917.ES.2018.23.15.17-00240

DO - 10.2807/1560-7917.ES.2018.23.15.17-00240

M3 - Article

VL - 23

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

IS - 15

ER -