Pepsin concentration in gastroduodenal biopsy homogenates in chronic ulcer disease

Fabio Vianello, Francesco Di Mario, Mario Plebani, Bastianello Germana, Pierluigi Dal Santo, Gioacchino Leandro, Paola Dotto, Stefano Andrea Grassi, Giuseppe Battaglia, Remo Naccarato

Research output: Contribution to journalArticle


A modification of Berstad's spectrophotometric method was tested and proved capable of detecting pepsin concentrations in mucosal perendoscopic biopsy homogenates. The relationship between this parameter and pepsin in gastric juice and pepsinogen group I in serum and in biopsy homogenates was analyzed. From the biochemical point of view, the assay was found sufficiently accurate. Mucosal pepsinogen group I, but not mucosal pepsin, concentration was found higher in gastric and duodenal ulcer patients than in controls. Patients with corpus-fundic gastric ulcer showed significantly lower mucosal pepsin and mucosal pepsinogen group (PG) I. Aging and smoking did not influence either parameter but male duodenal ulcer subjects presented higher mucosal pepsinogen group I concentration. The lack of any relationship between serum and mucosal PG I and between pepsin in gastric juice and in mucosa raises a question, at least in methodological terms, about the validity of using serum pepsinogen group I and pepsin as indicators of peptic output.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalDigestive Diseases and Sciences
Issue number2
Publication statusPublished - Feb 1994


  • mucosal pepsin
  • mucosal pepsinogen group I
  • pepsin
  • serum group I pepsinogen
  • ulcer disease

ASJC Scopus subject areas

  • Gastroenterology

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