Background. Peptic ulcer has multifactorial aetiology, including genetic factors. We have identified a family with pepsinogen Group A levels higher than normal, with a high prevalence of ulcer disease and a low prevalence of Helicobacter pylori infection. Aims. Performing linkage analysis in the identified family. Patients and Methods. We examined the segregation of pepsinogens with microsatellite dinucleotide repeat DNA markers along chromosome 11 (D11S480, PYGM) for pepsinogen Group A and along chromosome 6 (D6S105, D6S1610, TRMI) for pepsinogen Group C. Results. In markers examined along chromosome 11, linkage analysis provided no evidence for significant causal mutation but, controlling for some risk factors we observed that the probability of falling ill, increases. The linkage analysis along chromosome 6 for pepsinogen Group C did not show a uniform genetic profile. Conclusions. This study evaluates the hypothesis of peptic ulcer inheritance at least in a small group of patients without the common risk factors.
|Number of pages||8|
|Journal||Digestive and Liver Disease|
|Publication status||Published - Jan 2000|
- Hyper-pepsinogen group A
- Linkage analysis
- Peptic ulcer
ASJC Scopus subject areas