Peptic ulcer inheritance in patients with elevated serum pepsinogen group A levels and without infection of Helicobacter pylori

T. Del Bianco, R. Borgoni, P. Del Bianco, P. Cedaro, F. Vianello, G. A. Danieli, F. Di Mario

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Peptic ulcer has multifactorial aetiology, including genetic factors. We have identified a family with pepsinogen Group A levels higher than normal, with a high prevalence of ulcer disease and a low prevalence of Helicobacter pylori infection. Aims. Performing linkage analysis in the identified family. Patients and Methods. We examined the segregation of pepsinogens with microsatellite dinucleotide repeat DNA markers along chromosome 11 (D11S480, PYGM) for pepsinogen Group A and along chromosome 6 (D6S105, D6S1610, TRMI) for pepsinogen Group C. Results. In markers examined along chromosome 11, linkage analysis provided no evidence for significant causal mutation but, controlling for some risk factors we observed that the probability of falling ill, increases. The linkage analysis along chromosome 6 for pepsinogen Group C did not show a uniform genetic profile. Conclusions. This study evaluates the hypothesis of peptic ulcer inheritance at least in a small group of patients without the common risk factors.

Original languageEnglish
Pages (from-to)12-19
Number of pages8
JournalDigestive and Liver Disease
Volume32
Issue number1
Publication statusPublished - Jan 2000

Keywords

  • Heredity
  • Hyper-pepsinogen group A
  • Linkage analysis
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

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