Peptide Patterns as Discriminating Biomarkers in Plasma of Patients With Familial Adenomatous Polyposis

Lisa Agatea, Sara Crotti, Eugenio Ragazzi, Chiara Bedin, Emanuele Urso, Isabella Mammi, Pietro Traldi, Salvatore Pucciarelli, Donato Nitti, Marco Agostini

Research output: Contribution to journalArticle

Abstract

Micro-Abstract We use the mass spectrometry technique for the detection of circulating peptides in patients with familial adenomatous polyposis (FAP). We describe a FAP-specific fingerprint that allows early identification of the disease and neoplastic transformation. Our results are relevant because they could postpone preventive surgery as long as possible, improving the quality of life of patients with FAP.

Original languageEnglish
Pages (from-to)e75-e92
JournalClinical Colorectal Cancer
Volume15
Issue number3
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • Circulating plasma peptides
  • Colon cancer
  • Complement system C3f
  • Matrix-assisted laser desorption/ionization
  • Switch adenoma-carcinoma

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Peptide Patterns as Discriminating Biomarkers in Plasma of Patients With Familial Adenomatous Polyposis'. Together they form a unique fingerprint.

  • Cite this

    Agatea, L., Crotti, S., Ragazzi, E., Bedin, C., Urso, E., Mammi, I., Traldi, P., Pucciarelli, S., Nitti, D., & Agostini, M. (2016). Peptide Patterns as Discriminating Biomarkers in Plasma of Patients With Familial Adenomatous Polyposis. Clinical Colorectal Cancer, 15(3), e75-e92. https://doi.org/10.1016/j.clcc.2015.12.002