Peptide specificity in the recognition of MHC class I by natural killer cell clones

Mauro S. Malnati, Marta Peruzzi, Kenneth C. Parker, William E. Biddison, Ermanno Ciccone, Alessandro Moretta, Eric O. Long

Research output: Contribution to journalArticlepeer-review

Abstract

Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

Original languageEnglish
Pages (from-to)1016-1018
Number of pages3
JournalScience
Volume267
Issue number5200
Publication statusPublished - 1995

ASJC Scopus subject areas

  • General

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