Peptide specificity in the recognition of MHC class I by natural killer cell clones

Mauro S. Malnati, Marta Peruzzi, Kenneth C. Parker, William E. Biddison, Ermanno Ciccone, Alessandro Moretta, Eric O. Long

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

Original languageEnglish
Pages (from-to)1016-1018
Number of pages3
JournalScience
Volume267
Issue number5200
Publication statusPublished - 1995

Fingerprint

Major Histocompatibility Complex
Natural Killer Cells
Clone Cells
Peptides
Binding Sites
Amino Acids
HLA-B*27:05 antigen

ASJC Scopus subject areas

  • General

Cite this

Malnati, M. S., Peruzzi, M., Parker, K. C., Biddison, W. E., Ciccone, E., Moretta, A., & Long, E. O. (1995). Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science, 267(5200), 1016-1018.

Peptide specificity in the recognition of MHC class I by natural killer cell clones. / Malnati, Mauro S.; Peruzzi, Marta; Parker, Kenneth C.; Biddison, William E.; Ciccone, Ermanno; Moretta, Alessandro; Long, Eric O.

In: Science, Vol. 267, No. 5200, 1995, p. 1016-1018.

Research output: Contribution to journalArticle

Malnati, MS, Peruzzi, M, Parker, KC, Biddison, WE, Ciccone, E, Moretta, A & Long, EO 1995, 'Peptide specificity in the recognition of MHC class I by natural killer cell clones', Science, vol. 267, no. 5200, pp. 1016-1018.
Malnati MS, Peruzzi M, Parker KC, Biddison WE, Ciccone E, Moretta A et al. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science. 1995;267(5200):1016-1018.
Malnati, Mauro S. ; Peruzzi, Marta ; Parker, Kenneth C. ; Biddison, William E. ; Ciccone, Ermanno ; Moretta, Alessandro ; Long, Eric O. / Peptide specificity in the recognition of MHC class I by natural killer cell clones. In: Science. 1995 ; Vol. 267, No. 5200. pp. 1016-1018.
@article{feb14667e72a477f9ec9f35539b40f1d,
title = "Peptide specificity in the recognition of MHC class I by natural killer cell clones",
abstract = "Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.",
author = "Malnati, {Mauro S.} and Marta Peruzzi and Parker, {Kenneth C.} and Biddison, {William E.} and Ermanno Ciccone and Alessandro Moretta and Long, {Eric O.}",
year = "1995",
language = "English",
volume = "267",
pages = "1016--1018",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5200",

}

TY - JOUR

T1 - Peptide specificity in the recognition of MHC class I by natural killer cell clones

AU - Malnati, Mauro S.

AU - Peruzzi, Marta

AU - Parker, Kenneth C.

AU - Biddison, William E.

AU - Ciccone, Ermanno

AU - Moretta, Alessandro

AU - Long, Eric O.

PY - 1995

Y1 - 1995

N2 - Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

AB - Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.

UR - http://www.scopus.com/inward/record.url?scp=0028920065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028920065&partnerID=8YFLogxK

M3 - Article

C2 - 7863326

AN - SCOPUS:0028920065

VL - 267

SP - 1016

EP - 1018

JO - Science

JF - Science

SN - 0036-8075

IS - 5200

ER -