Peptidic Biomaterials: From Self-Assembling to Regenerative Medicine

Raffaele Pugliese, Fabrizio Gelain

Research output: Contribution to journalArticlepeer-review

Abstract

Peptidic biomaterials represent a particularly exciting topic in regenerative medicine. Peptidic scaffolds can be specifically designed for biomimetic customization for targeted therapy. The field is at a pivotal point where preclinical research is being translated into clinics, so it is crucial to understand the theory and describe the status of this rapidly developing technology. In this review, we highlight major advantages and current limitations of self-assembling peptide-based biomaterials, and we discuss the most widely used classes of assembling peptides, describing recent and promising approaches in tissue engineering, drug delivery, and clinics. We also suggest design strategies and hurdles that still need to be overcome to fully exploit their therapeutic potential.

Original languageEnglish
Pages (from-to)145-158
Number of pages14
JournalTrends in Biotechnology
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Journal Article
  • Review

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