Peptidyl-prolyl isomerases

A full cast of critical actors in cardiovascular diseases

Gianluca Lorenzo Perrucci, Aoife Gowran, Marco Zanobini, Maurizio Colognesi Capogrossi, Giulio Pompilio, Patrizia Nigro

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

Original languageEnglish
Pages (from-to)353-364
Number of pages12
JournalCardiovascular Research
Volume106
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Peptidylprolyl Isomerase
Cardiovascular Diseases
Immunophilins
Tacrolimus Binding Proteins
Cyclophilins
Protein Folding
Vascular Diseases
Blood Vessels
Cardiac Arrhythmias
Heart Diseases
Atherosclerosis
Pathologic Constriction
Heart Failure
Hypertension
Calcium
Gene Expression

Keywords

  • Cardiovascular disease
  • Cyclophilins
  • FKBPs
  • Parvulins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology
  • Medicine(all)

Cite this

Peptidyl-prolyl isomerases : A full cast of critical actors in cardiovascular diseases. / Perrucci, Gianluca Lorenzo; Gowran, Aoife; Zanobini, Marco; Capogrossi, Maurizio Colognesi; Pompilio, Giulio; Nigro, Patrizia.

In: Cardiovascular Research, Vol. 106, No. 3, 01.06.2015, p. 353-364.

Research output: Contribution to journalArticle

Perrucci, Gianluca Lorenzo ; Gowran, Aoife ; Zanobini, Marco ; Capogrossi, Maurizio Colognesi ; Pompilio, Giulio ; Nigro, Patrizia. / Peptidyl-prolyl isomerases : A full cast of critical actors in cardiovascular diseases. In: Cardiovascular Research. 2015 ; Vol. 106, No. 3. pp. 353-364.
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