Perceived challenges and attitudes to regimen and product selection from Italian haemophilia treaters: The 2013 AICE survey

M. Franchini, A. Coppola, A. Rocino, E. Zanon, M. Morfini, Arianna Accorsi, Anna Brigida Aru, Chiara Biasoli, Isabella Cantori, Giancarlo Castaman, Simone Cesaro, Carlo Ciabatta, Raimondo De Cristofaro, Grazia Delios, Giovanni Di Minno, Marco D'Incà, Alfredo Dragani, Cosimo Pietro Ettorre, Fabio Gagliano, Gabriella GambaGiorgio Gandini, Paola Giordano, Gaetano Giuffrida, Paolo Gresele, Caterina Latella, Matteo Luciani, Maurizio Margaglione, Marco Marietta, Maria Gabriella Mazzucconi, Maria Messina, Angelo Claudio Molinari, Lucia Dora Notarangelo, Emily Oliovecchio, Flora Peyvandi, Gavino Piseddu, Gina Rossetti, Vincenza Rossi, Elena Santagostino, Mario Schiavoni, Piercarla Schinco, Maria Luisa Serino, Annarita Tagliaferri, Sophie Testa

Research output: Contribution to journalArticle

Abstract

Despite great advances in haemophilia care in the last 20 years, a number of questions on haemophilia therapy remain unanswered. These debated issues primarily involve the choice of the product type (plasma-derived vs. recombinant) for patients with different characteristics: specifically, if they were infected by blood-borne virus infections, and if they bear high or low risk of inhibitor development. In addition, the most appropriate treatment regimen in non-inhibitor and inhibitor patients compel physicians operating at the haemophilia treatment centres (HTCs) to take important therapeutic decisions, which are often based on their personal clinical experience rather than on evidence-based recommendations from published literature data. To know the opinion on the most controversial aspects in haemophilia care of Italian expert physicians, who are responsible for common clinical practice and therapeutic decisions, we have conducted a survey among the Directors of HTCs affiliated to the Italian Association of Haemophilia Centres (AICE). A questionnaire, consisting of 19 questions covering the most important topics related to haemophilia treatment, was sent to the Directors of all 52 Italian HTCs. Forty Directors out of 52 (76.9%) responded, accounting for the large majority of HTCs affiliated to the AICE throughout Italy. The results of this survey provide for the first time a picture of the attitudes towards clotting factor concentrate use and product selection of clinicians working at Italian HTCs.

Original languageEnglish
JournalHaemophilia
Volume20
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Factor concentrates
  • Haemophilia treatment
  • Inhibitor
  • Prophylaxis
  • Survey
  • Viral safety

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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    Franchini, M., Coppola, A., Rocino, A., Zanon, E., Morfini, M., Accorsi, A., Aru, A. B., Biasoli, C., Cantori, I., Castaman, G., Cesaro, S., Ciabatta, C., De Cristofaro, R., Delios, G., Di Minno, G., D'Incà, M., Dragani, A., Ettorre, C. P., Gagliano, F., ... Testa, S. (2014). Perceived challenges and attitudes to regimen and product selection from Italian haemophilia treaters: The 2013 AICE survey. Haemophilia, 20(2). https://doi.org/10.1111/hae.12334