Perception of dyspnea in patients with neuromuscular disease

B. Lanini, G. Misuri, F. Gigliotti, I. Iandelli, A. Pizzi, I. Romagnoli, G. Scano

Research output: Contribution to journalArticle

Abstract

Background: The perception of dyspnea is not a prominent complaint of resting patients with neuromuscular disease (NMD). To our knowledge, no study has been addressed at evaluating the interrelationships among lung mechanics, respiratory motor output, and the perception of dyspnea in patients with NMD receiving ventilatory stimulation. Material: Eleven patients with NMD (mean ± SD age, 44 ± 11.8 years; 5 men) of different etiology and a group of normal subjects matched for age and sex (control subjects). Methods: While patients were breathing room air, lung volumes, arterial blood gases, the pattern of breathing (minute ventilation [V̇E], tidal volume [VT], respiratory frequency, inspiratory time), and maximal (less negative) esophageal pressure during a sniff maneuver (Pessn), as an index of inspiratory muscle strength, were measured. Then we evaluated the response to hypercapnic-hyperoxic stimulation (hypercapnic-hyperoxic rebreathing test [RT]) in terms of breathing pattern, inspiratory swing of pleural pressure (Pessw), and inspiratory effort (Pessw[%Pessn]). During the RT, dyspnea was assessed every 30 s using a modified Borg scale (0 to 10). Results: Pulmonary volumes were reduced in seven patients, and PCO2 was out of proportion to V̇E in four patients. Group Pessn was 42.8 ± 23.6 cm H2O in patients and 107 ± 20.4 cm H2O in control subjects (p <0.001). Dynamic elastance (Eldyn) [p = 0.0016] and Pessw(%Pessn) [p <0.0005] were higher in patients. During the RT, Borg/CO2, Pessw(%Pessn)/CO2, and Borg/Pessw(%Pessn) were similar in the two groups, while V̇E/CO2 and VT/CO2 were lower in patients (p <0.0002 for both). As a consequence, for unit change in VT (percentage of predicted vital capacity [%VC]), greater changes in Pessw(%Pessn) were associated with greater Borg scores in patients. Baseline Eldyn related to Pessw(%Pessn)/VT(%VC) during hypercapnia (r2 = 0.85), an index of neuroventilatory coupling of the ventilatory pump (NVC). NVC predicted a good amount of the variability in Borg/V̈E (r2 = 0.46, p <0.02). Conclusions: In this subset of NMD patients during hypercapnic stimulation, a normal inspiratory motor output per unit change in PCO2 results in a shallow breathing pattern. The consequent impairment of NVC underlies the higher scoring of dyspnea in these patients.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalChest
Volume120
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Breathing pattern
  • Dyspnea
  • Neuromuscular coupling
  • Neuromuscular disease
  • Respiratory drive
  • Respiratory muscles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Perception of dyspnea in patients with neuromuscular disease'. Together they form a unique fingerprint.

  • Cite this

    Lanini, B., Misuri, G., Gigliotti, F., Iandelli, I., Pizzi, A., Romagnoli, I., & Scano, G. (2001). Perception of dyspnea in patients with neuromuscular disease. Chest, 120(2), 402-408. https://doi.org/10.1378/chest.120.2.402