Percutaneous closure of ventricular septal defects in children aged

Gianfranco Butera, Mario Carminati, Massimo Chessa, Luciane Piazza, Raul Abella, Diana Gabriella Negura, Alessandro Giamberti, Bussadori Claudio, Angelo Micheletti, Youssef Tammam, Alessandro Frigiola

Research output: Contribution to journalArticlepeer-review


Aims: The aim of the article is to study the safety, efficacy, and follow-up of percutaneous closure of muscular ventricular septal defect (mVSD) and perimembranous ventricular septal defect (pmVSD) in children. Methods and results: Between January 2000 and June 2005, among 140 patients who underwent percutaneous closure of an mVSD or a pmVSD, 88 were aged lt;12. Two different Amplatzer devices were used: the mVSD occluder and the pmVSD occluder. Mean age and weight at procedure were 4.5±3.3 years and 18.7±11.2 kg, respectively. Percutaneous closure was successfully achieved in 83 subjects (94%). No deaths occurred. Thirteen patients (14.7%) had early complications: device embolization (n=4), vascular complications (n=3), and rhythm abnormalities (n=6). These were transient complications in all but one case [1.1% complete atrioventricular block (cAVB) needing pacemaker implantation]. During a median follow-up of 24 months, three subjects treated for a pmVSD needed pacemaker implantation due to the occurrence of cAVB. Multivariable analysis using Cox's proportional hazard regression showed that age was the only risk factor associated with the occurrence of cAVB (P=0.028; relative risk: 0.25). Conclusion: Percutaneous closure of mVSD and pmVSD in children can be performed safely and successfully. The occurrence of cAVB is a major concern in young children with pmVSD.

Original languageEnglish
Pages (from-to)2889-2895
Number of pages7
JournalEuropean Heart Journal
Issue number23
Publication statusPublished - Dec 2006


  • Children
  • Percutaneous
  • Septal defect
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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