Percutaneous Computed Tomography-Guided Lung Biopsies using a Virtual Navigation Guidance: Our Experience

Giancarlo Iannelli, Rocchina Caivano, Antonio Villonio, Vittorio Semeraro, Nicola Maria Lucarelli, Maria Porzia Ganimede, Vito Gisone, Giuseppina Dinardo, Sante Bruno, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the effectiveness of a virtual CT-guided navigation system (Sirio-MASMEC Biomed) in performing lung biopsies, with greater attention to lesions smaller than 1 cm, compared to the traditional procedure. Methods: This study was approved by the Ethics Committee of our Institute. Two hundred patients were prospectively selected. Of these, 100 were subjected to percutaneous procedure with the use of Sirio and 100 to traditional CT-guided percutaneous procedure. The two methods were compared in terms of absorbed dose, procedure time, complications, and number of non-diagnostic specimens (diagnostic success). Results: Sirio has shown a significant reduction in the absorbed dose and procedure times (p < 0.05), with a lower incidence of complications compared to the traditional procedure. Sirio has also allowed to carry out biopsies of lesions’ diameter ≤10 mm, obtaining fewer non diagnostic specimens thus resulting more effective in terms of diagnostic success. Conclusions: The use of Sirio in sampling biopsy showed a statistically significant reduction in terms of performed scans and procedural time with lower incidence of post-procedural complications compared to the traditional percutaneous procedure, especially for lesions ≤10 mm. The best diagnostic result, the reduction of the dose absorbed and procedural complications makes the procedures more reliable, safety and less invasive. In addition, the reduction of execution time will increase the number of daily interventional procedures improving clinical management.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalCancer Investigation
Issue number6
Publication statusPublished - Jul 3 2018


  • CT guided biopsy
  • Interventional radiology
  • Lung biopsy
  • Virtual navigation system

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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