Percutaneous edge-to-edge repair in high-risk and elderly patients with degenerative mitral regurgitation: Midterm outcomes in a single-center experience

Maurizio Taramasso, Francesco Maisano, Paolo Denti, Azeem Latib, Giovanni La Canna, Antonio Colombo, Ottavio Alfieri

Research output: Contribution to journalArticle

Abstract

Objective The study objective was to report the midterm outcomes of MitraClip implantation in inoperable or high-risk surgical candidates with degenerative mitral regurgitation.

Results Forty-eight high-risk consecutive patients with severe degenerative mitral regurgitation underwent MitraClip implantation (mean age, 78.5 ± 10.8 years; 56.6% of the patients were aged ≥80 years). Mean Society of Thoracic Surgeons score was 12% ± 10%, and 71% were in New York Heart Association class III or IV. Mean left ventricular ejection fraction was 57% ± 11%. The device was successfully implanted in 47 of 48 patients (98%). In-hospital mortality was 2%. The median intensive care unit stay was 22 hours; patients were discharged from the hospital in an average of 4.5 ± 2.4 days. Predischarge echocardiography showed a mitral regurgitation reduction to grade 2+ or less in 43 of 47 patients (91.5%). Actuarial survival was 89% ± 5.2% and 70.2% ± 9% at 1 and 2 years, respectively (82% ± 9% in patients aged

Conclusions MitraClip therapy is a valuable alternative to surgery in high-risk and elderly patients with degenerative mitral regurgitation. Clinical benefits also are obtained in octogenarians.

Original languageEnglish
Pages (from-to)2743-2750
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume148
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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Mitral Valve Insufficiency
Hospital Mortality
Stroke Volume
Intensive Care Units
Echocardiography
Equipment and Supplies
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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Percutaneous edge-to-edge repair in high-risk and elderly patients with degenerative mitral regurgitation : Midterm outcomes in a single-center experience. / Taramasso, Maurizio; Maisano, Francesco; Denti, Paolo; Latib, Azeem; La Canna, Giovanni; Colombo, Antonio; Alfieri, Ottavio.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 148, No. 6, 01.12.2014, p. 2743-2750.

Research output: Contribution to journalArticle

Taramasso, Maurizio ; Maisano, Francesco ; Denti, Paolo ; Latib, Azeem ; La Canna, Giovanni ; Colombo, Antonio ; Alfieri, Ottavio. / Percutaneous edge-to-edge repair in high-risk and elderly patients with degenerative mitral regurgitation : Midterm outcomes in a single-center experience. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 148, No. 6. pp. 2743-2750.
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