Percutaneous endoscopic gastrostomy and enteral nutrition in amyotrophic lateral sclerosis

L. Mazzini, T. Corrà, M. Zaccala, G. Mora, M. Del Piano, M. Galante

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Bulbar involvement in amyotrophic lateral sclerosis (ALS) is often related to a worse prognosis on account of the higher risk of pulmonary aspiration and undernutrition due to dysphagia. The aim of our study was to assess the effects of enteral feeding by percutaneous endoscopic gastrostomy (PEG) in a long-term follow-up of ALS patients. We report the results of PEG in 31 ALS patients with bulbar involvement. The patients were observed at 3-monthly intervals over a period of 2 years after PEG. All the data were compared with those obtained from a control group of 35 ALS patients who refused PEG. Mortality did not differ significantly between the two groups of patients during the first 6 months of observation, whereas after this period it was lower in the PEG group. In the patients who had had PEG, the body mass index showed a mild but statistically significant improvement after tube insertion while in the control group it decreased significantly. The findings of this study demonstrate that PEG can improve survival in elderly and young ALS patients with bulbar involvement; it enhances their quality of life and helps their integration in their social and family surroundings. We think that PEG should be included symptomatic treatment of all ALS patients with bulbar involvement from the onset of symptoms.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalJournal of Neurology
Volume242
Issue number10
DOIs
Publication statusPublished - Oct 1995

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Gastrostomy
Amyotrophic Lateral Sclerosis
Enteral Nutrition
Control Groups
Deglutition Disorders
Malnutrition
Body Mass Index
Quality of Life
Observation
Lung
Survival
Mortality

Keywords

  • Amyotrophic lateral sclerosis
  • Dysphagia
  • Enteral feeding
  • Undernutrition

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Percutaneous endoscopic gastrostomy and enteral nutrition in amyotrophic lateral sclerosis. / Mazzini, L.; Corrà, T.; Zaccala, M.; Mora, G.; Del Piano, M.; Galante, M.

In: Journal of Neurology, Vol. 242, No. 10, 10.1995, p. 695-698.

Research output: Contribution to journalArticle

Mazzini, L. ; Corrà, T. ; Zaccala, M. ; Mora, G. ; Del Piano, M. ; Galante, M. / Percutaneous endoscopic gastrostomy and enteral nutrition in amyotrophic lateral sclerosis. In: Journal of Neurology. 1995 ; Vol. 242, No. 10. pp. 695-698.
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