Percutaneous ethanol injection (PEI): Thyroid cysts and other neck lesions

Andrea Frasoldati, Roberto Valcavi

Research output: Chapter in Book/Report/Conference proceedingChapter


Ethanol injection causes irreversible tissue damage through cellular dehydration, protein denaturation, coagulative necrosis, and small vessel thrombosis leading to hemorrhagic infarct and reactive fibrosis. The sclerosing properties of ethanol have prompted its use in the treatment of various malignant or benign lesions such us hepatocellular carcinoma, adrenal adenoma, parathyroid adenoma, or hyperplasia. Percutaneous ethanol injection (PEI) for the treatment of thyroid lesions was introduced into clinical practice in 1990. This technique was initially proposed as an alternative to surgery and radioiodine administration in the management of autonomous functioning nodules. While the use of PEI for this purpose has sensibly decreased, ethanol sclerosing properties have been successfully applied in the treatment of thyroid cystic lesions. The present chapter will deal with PEI applications to thyroid lesions, focusing on the treatment of thyroid cysts. PEI therapy of other neck lesions (e.g., parathyroid, lymph nodes) will also be briefly addressed.

Original languageEnglish
Title of host publicationThyroid Ultrasound and Ultrasound-Guided FNA: Second Edition
PublisherSpringer US
Number of pages17
ISBN (Print)9780387776330
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Percutaneous ethanol injection (PEI): Thyroid cysts and other neck lesions'. Together they form a unique fingerprint.

Cite this