Percutaneous intraductal radiofrequency ablation is a safe treatment for malignant biliary obstruction: Feasibility and early results

Malkhaz Mizandari, Madhava Pai, Feng Xi, Vlastimil Valek, Andrasina Tomas, Pietro Quaretti, Rita Golfieri, Cristina Mosconi, Ao Guokun, Charis Kyriakides, Robert Dickinson, Joanna Nicholls, Nagy Habib

Research output: Contribution to journalArticlepeer-review


Purpose: Previous clinical studies have shown the safety and efficacy of this novel radiofrequency ablation catheter when used for endoscopic palliative procedures. We report a retrospective study with the results of first in man percutaneous intraductal radiofrequency ablation in patients with malignant biliary obstruction. Methods: Thirty-nine patients with inoperable malignant biliary obstruction were included. These patients underwent intraductal biliary radiofrequency ablation of their malignant biliary strictures following external biliary decompression with an internal-external biliary drainage. Following ablation, they had a metal stent inserted. Results: Following this intervention, there were no 30-day mortality, hemorrhage, bile duct perforation, bile leak, or pancreatitis. Of the 39 patients, 28 are alive and 10 patients are dead with a median survival of 89.5 (range 14-260) days and median stent patency of 84.5 (range 14-260) days. One patient was lost to follow-up. All but one patient had their stent patent at the time of last follow-up or death. One patient with stent blockage at 42 days postprocedure underwent percutaneous transhepatic drain insertion and restenting. Among the patients who are alive (n = 28) the median stent patency was 92 (range 14-260) days, whereas the patients who died (n = 10) had a median stent patency of 62.5 (range 38-210) days. Conclusions: In this group of patients, it appears that this new approach is feasible and safe. Efficacy remains to be proven in future, randomized, prospective studies.

Original languageEnglish
Pages (from-to)814-819
Number of pages6
JournalCardioVascular and Interventional Radiology
Issue number3
Publication statusPublished - Jun 2013


  • Bile duct
  • Biliary
  • Cancer
  • Hepatic
  • Radiofrequency ablation
  • Recanalization
  • Stenting

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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