Abstract
Background Chronic mitral regurgitation (MR) often leads to diminished right ventricular (RV) function due to long-standing pressure and volume overload. Surgical intervention often adds to the preexisting RV dysfunction. Percutaneous mitral valve (MV) repair can reduce MR, but to what extent this affects the right ventricle is unknown.
Methods Consecutive patients scheduled for percutaneous MV repair using the MitraClip system underwent transthoracic echocardiography at baseline and at 1- and 6-month follow-up. RV systolic function was evaluated using five echocardiographic parameters. RV afterload was evaluated using systolic pulmonary arterial pressure and the mean MV pressure gradient. Residual MR was defined as grade ≥ 3 and mitral stenosis (MS) as a mean MV pressure gradient ≥ 5 mm Hg.
Results Sixty-eight patients (52% men; mean age, 75 ± 10 years) were included. Six months after MitraClip implantation, there were no significant changes in any of the RV parameters. MR decreased (P
Conclusions Percutaneous MV repair, in contrast to surgical repair or replacement, does not negatively affect RV function. After repair, RV afterload and New York Heart Association functional class are improved in the case of successful repair but adversely affected in the presence of both residual MR and MS.
| Original language | English |
|---|---|
| Pages (from-to) | 1098-1106 |
| Number of pages | 9 |
| Journal | Journal of the American Society of Echocardiography |
| Volume | 27 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- MitraClip
- Mitral regurgitation
- Mitral stenosis
- Percutaneous mitral valve repair
- Right ventricular function
- Transthoracic echocardiography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
Percutaneous mitral valve repair preserves right ventricular function. / Van Riel, Annelieke C M J; Boerlage-Van Dijk, Kirsten; De Bruin-Bon, Rianne H A C M; Araki, Motoharu; Koch, Karel T.; Vis, M. Marije; Meregalli, Paola G.; Van Den Brink, Renée B A; Piek, Jan J.; Mulder, Barbara J M; Baan, Jan; Bouma, Berto J.
In: Journal of the American Society of Echocardiography, Vol. 27, No. 10, 01.10.2014, p. 1098-1106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Percutaneous mitral valve repair preserves right ventricular function
AU - Van Riel, Annelieke C M J
AU - Boerlage-Van Dijk, Kirsten
AU - De Bruin-Bon, Rianne H A C M
AU - Araki, Motoharu
AU - Koch, Karel T.
AU - Vis, M. Marije
AU - Meregalli, Paola G.
AU - Van Den Brink, Renée B A
AU - Piek, Jan J.
AU - Mulder, Barbara J M
AU - Baan, Jan
AU - Bouma, Berto J.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background Chronic mitral regurgitation (MR) often leads to diminished right ventricular (RV) function due to long-standing pressure and volume overload. Surgical intervention often adds to the preexisting RV dysfunction. Percutaneous mitral valve (MV) repair can reduce MR, but to what extent this affects the right ventricle is unknown.Methods Consecutive patients scheduled for percutaneous MV repair using the MitraClip system underwent transthoracic echocardiography at baseline and at 1- and 6-month follow-up. RV systolic function was evaluated using five echocardiographic parameters. RV afterload was evaluated using systolic pulmonary arterial pressure and the mean MV pressure gradient. Residual MR was defined as grade ≥ 3 and mitral stenosis (MS) as a mean MV pressure gradient ≥ 5 mm Hg.Results Sixty-eight patients (52% men; mean age, 75 ± 10 years) were included. Six months after MitraClip implantation, there were no significant changes in any of the RV parameters. MR decreased (P Conclusions Percutaneous MV repair, in contrast to surgical repair or replacement, does not negatively affect RV function. After repair, RV afterload and New York Heart Association functional class are improved in the case of successful repair but adversely affected in the presence of both residual MR and MS.
AB - Background Chronic mitral regurgitation (MR) often leads to diminished right ventricular (RV) function due to long-standing pressure and volume overload. Surgical intervention often adds to the preexisting RV dysfunction. Percutaneous mitral valve (MV) repair can reduce MR, but to what extent this affects the right ventricle is unknown.Methods Consecutive patients scheduled for percutaneous MV repair using the MitraClip system underwent transthoracic echocardiography at baseline and at 1- and 6-month follow-up. RV systolic function was evaluated using five echocardiographic parameters. RV afterload was evaluated using systolic pulmonary arterial pressure and the mean MV pressure gradient. Residual MR was defined as grade ≥ 3 and mitral stenosis (MS) as a mean MV pressure gradient ≥ 5 mm Hg.Results Sixty-eight patients (52% men; mean age, 75 ± 10 years) were included. Six months after MitraClip implantation, there were no significant changes in any of the RV parameters. MR decreased (P Conclusions Percutaneous MV repair, in contrast to surgical repair or replacement, does not negatively affect RV function. After repair, RV afterload and New York Heart Association functional class are improved in the case of successful repair but adversely affected in the presence of both residual MR and MS.
KW - MitraClip
KW - Mitral regurgitation
KW - Mitral stenosis
KW - Percutaneous mitral valve repair
KW - Right ventricular function
KW - Transthoracic echocardiography
UR - http://www.scopus.com/inward/record.url?scp=84907602043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907602043&partnerID=8YFLogxK
U2 - 10.1016/j.echo.2014.06.001
DO - 10.1016/j.echo.2014.06.001
M3 - Article
C2 - 25042410
AN - SCOPUS:84907602043
VL - 27
SP - 1098
EP - 1106
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 10
ER -