Abstract
Purpose: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. Methods: Fifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O2-O3 mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ2) tests. Results: Our initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded. Conclusion: Ozone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations.
| Original language | English |
|---|---|
| Pages (from-to) | 1231-1241 |
| Number of pages | 11 |
| Journal | Neuroradiology |
| Volume | 60 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2018 |
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Keywords
- Lumbar disc herniation
- Oswestry Disability Index
- Ozone
- Pain
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Percutaneous ozone nucleolysis for lumbar disc herniation. / Ezeldin, Mohamed; Leonardi, Marco; Princiotta, Ciro; Dall’olio, Massimo; Tharwat, Mohammed; Zaki, Mohammed; Abdel-Wanis, Mohamed E.; Cirillo, Luigi.
In: Neuroradiology, Vol. 60, No. 11, 01.11.2018, p. 1231-1241.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Percutaneous ozone nucleolysis for lumbar disc herniation
AU - Ezeldin, Mohamed
AU - Leonardi, Marco
AU - Princiotta, Ciro
AU - Dall’olio, Massimo
AU - Tharwat, Mohammed
AU - Zaki, Mohammed
AU - Abdel-Wanis, Mohamed E.
AU - Cirillo, Luigi
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Luigi Cirillo). Pubblicata "CORRECTION" per modifica di affiliazione (inserito nel pdf della pubblicazione qui allegato).
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Purpose: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. Methods: Fifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O2-O3 mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ2) tests. Results: Our initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded. Conclusion: Ozone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations.
AB - Purpose: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. Methods: Fifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O2-O3 mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ2) tests. Results: Our initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded. Conclusion: Ozone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations.
KW - Lumbar disc herniation
KW - Oswestry Disability Index
KW - Ozone
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=85053506574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053506574&partnerID=8YFLogxK
U2 - 10.1007/s00234-018-2083-4
DO - 10.1007/s00234-018-2083-4
M3 - Article
C2 - 30206674
AN - SCOPUS:85053506574
VL - 60
SP - 1231
EP - 1241
JO - Neuroradiology
JF - Neuroradiology
SN - 0028-3940
IS - 11
ER -