Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: Long-term results in 117 patients

L. Solbiati, T. Livraghi, S. N. Goldberg, T. Ierace, F. Meloni, M. Dellanoce, L. Cova, E. F. Halpern, G. S. Gazelle

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To describe the results of an ongoing radio-frequency (RF) ablation study in patients with hepatic metastases from colorectal carcinoma. MATERIALS AND METHODS: In 117 patients, 179 metachronous colorectal carcinoma hepatic metastases (0.9 -9.6 cm in diameter) were treated with RF ablation by using 17-gauge internally cooled electrodes. Computed tomographic follow-up was performed every 4-6 months. Recurrent tumors were retreated when feasible. Time to new metastases and death for each patient and time to local recurrence for individual lesions were modeled with Kaplan-Meier analysis. Modeling determined the effect of number of metastases on the time to new metastases and death and effect of tumor size on local recurrence. RESULTS: Estimated median survival was 36 months (95% Cl; 28, 52 months). Estimated 1, 2, and 3-year survival rates were 93%, 69%, and 46%, respectively. Survival was not significantly related to number of metastases treated. In 77 (66%) of 117 patients, new metastases were observed at follow-up. Estimated median time until new metastases was 12 months (95% Cl; 10, 18 months). Percentages of patients with no new metastases after initial treatment at 1 and 2 years were 49% and 35%, respectively. Time to new metastases was not significantly related to number of metastases. Seventy (39%) of 179 lesions developed local recurrence after treatment. Of these, 54 were observed by 6 months and 67 by 1 year. No local recurrence was observed after 18 months. Frequency and time to local recurrence were related to lesion size (P ≤ .001). CONCLUSION: RF ablation is an effective method to treat hepatic metastases from colorectal carcinoma.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalRadiology
Volume221
Issue number1
Publication statusPublished - 2001

Keywords

  • Liver neoplasms, secondary, 761.33
  • Liver neoplasms, therapy, 761.1269
  • Radiofrequency (RF) ablation, 761.1269

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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