Percutaneous US-guided radio-frequency tissue ablation of liver metastases: Treatment and follow-up in 16 patients

Luigi Solbiati, Tiziana Ierace, S. Nahum Goldberg, Sandro Sironi, Tito Livraghi, Roberto Fiocca, Giorgio Servadio, Giorgio Rizzatto, Peter R. Mueller, Alessandro Del Maschio, G. Scott Gazelle

Research output: Contribution to journalArticlepeer-review


PURPOSE: To determine the potential efficacy of radio-frequency (RF) ablation of liver metastases during long-term follow-up. MATERIALS AND METHODS: Sixteen patients with 31 hepatic metastases were treated with percutaneous, ultrasound-guided RF ablation. RF was applied to monopolar electrodes (2-3-cm tip exposure) either individually or within a multiprobe array (two to four probes) for 6 minutes at 90°C over one to four treatment sessions per metastasis. RESULTS: In only one of 75 sessions, a moderate complication, self-limited intraperitoneal hemorrhage, was observed. Four patients (four lesions) underwent surgical resection 15-60 days after RF treatment. Residual, viable tumor was seen in all of these patients. The remaining 12 patients were followed up for 9-29 months (mean, 18.1 months). In these patients, 18 of 27 lesions remained stable or decreased in size and showed no enhancement at computed tomography and/or magnetic resonance imaging for at least 9 months. Two patients died of disseminated disease at 13 months and one at 16 months. Disease-free survival was achieved in eight patients. CONCLUSION: RF ablation appears to be a simple, safe, and potentially effective treatment for selected patients with liver metastases and may become a less invasive alternative to surgical therapy.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
Issue number1
Publication statusPublished - Jan 1997


  • Liver neoplasms, secondary
  • Liver neoplasms, therapy
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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