Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis

Azeem Latib, Matteo Montorfano, Filippo Figini, Francesco Maisano, Alaide Chieffo, Stefano Benussi, Raimondo Bellanca, Chiara Gerli, Pietro Spagnolo, Ottavio Alfieri, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation.

Original languageEnglish
Pages (from-to)397-398
Number of pages2
JournalJournal of Cardiovascular Medicine
Issue number6
Publication statusPublished - Jun 2012


  • radiation-induced aortic stenosis
  • small aortic annulus
  • transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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