Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis

Azeem Latib, Matteo Montorfano, Filippo Figini, Francesco Maisano, Alaide Chieffo, Stefano Benussi, Raimondo Bellanca, Chiara Gerli, Pietro Spagnolo, Ottavio Alfieri, Antonio Colombo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation.

Original languageEnglish
Pages (from-to)397-398
Number of pages2
JournalJournal of Cardiovascular Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Aortic Valve Stenosis
Young Adult
Radiotherapy
Radiation
Aortic Valve Insufficiency
Pulmonary Fibrosis
Hodgkin Disease
Thyroid Neoplasms
Lung Diseases
Prostheses and Implants
Carcinoma
Kidney
Drug Therapy
Therapeutics
Transcatheter Aortic Valve Replacement

Keywords

  • radiation-induced aortic stenosis
  • small aortic annulus
  • transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis. / Latib, Azeem; Montorfano, Matteo; Figini, Filippo; Maisano, Francesco; Chieffo, Alaide; Benussi, Stefano; Bellanca, Raimondo; Gerli, Chiara; Spagnolo, Pietro; Alfieri, Ottavio; Colombo, Antonio.

In: Journal of Cardiovascular Medicine, Vol. 13, No. 6, 06.2012, p. 397-398.

Research output: Contribution to journalArticle

Latib, Azeem ; Montorfano, Matteo ; Figini, Filippo ; Maisano, Francesco ; Chieffo, Alaide ; Benussi, Stefano ; Bellanca, Raimondo ; Gerli, Chiara ; Spagnolo, Pietro ; Alfieri, Ottavio ; Colombo, Antonio. / Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis. In: Journal of Cardiovascular Medicine. 2012 ; Vol. 13, No. 6. pp. 397-398.
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AU - Benussi, Stefano

AU - Bellanca, Raimondo

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