Percutaneous versus surgical closure of secundum atrial septal defects: A systematic review and meta-analysis of currently available clinical evidence

Gianfranco Butera, Giuseppe Biondi-Zoccai, Giuseppe Sangiorgi, Raul Abella, Alessandro Giamberti, Claudio Bussadori, Imad Sheiban, Zackhia Saliba, Tiberio Santoro, Gabriele Pelissero, Mario Carminati, Alessandro Frigiola

Research output: Contribution to journalArticle


Aims: To summarise data from studies comparing surgical (SC) versus percutaneous closure (PC) of atrial septal defects (ASDs). Methods and results: Electronic databases, journals and major international conference proceedings were systematically searched for pertinent clinical studies comparing the two methods of closure (percutaneous and surgical) published up to December 2008, including only those reporting on more than 20 patients. Primary end- points: occurrence of death and of total and major early complications. Thirteen original studies (3,082 patients) were included. All studies were non-randomised. One death was reported in the surgical group (0.08%; 95% C.I. 0-0.23%). Analysis of postprocedural complications showed a 31% rate (95% CI 21-41%) in SC patients and a 6.6% rate (95% CI 3.9-9.2%) in PC subjects. The adjusted OR for SC vs. PC total complications was 5.4 (95% CI 2.96-9.84; p

Original languageEnglish
Pages (from-to)377-385
Number of pages9
Issue number3
Publication statusPublished - Jul 2011



  • Atrial septal defect
  • Meta-analysis
  • Surgery
  • Systematic review
  • Transcatheter
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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