Percutaneous versus surgical closure of secundum atrial septal defect: Comparison of early results and complications

Gianfranco Butera, Mario Carminati, Massimo Chessa, Rana Youssef, Manuela Drago, Alessandro Giamberti, Giuseppe Pomè, Edoardo Bossone, Alessandro Frigiola

Research output: Contribution to journalArticle


Background: Surgical closure of atrial septal defect (ASD) provides excellent results. Given the increasing popularity of percutaneous techniques, a comparison between the 2 methods is needed. Methods: Between December 1988 and June 2003, we performed 1284 procedures in 1268 consecutive patients with isolated secundum ASD. Five hundred and thirty-three patients underwent surgical repair of ostium secundum ASD (group A). Seven hundred and fifty-one consecutive patients underwent percutaneous ASD closure (group B). The following outcomes were studied: mortality, morbidity, hospital stay, and efficacy. Results: There were no postoperative deaths. The overall rate of complications was higher in group A than in group B: 44% (95% CI 39.8%-48.2%) versus 6.9 % (95% CI 5%-8.7%) (P <.0001). Major complications were also more frequent in group A: 16% (95% CI 13%-19%) versus 3.6% (95% CI 2.2%-5.0%) (P = .002). Multiple logistic regression analysis showed that surgery was independently strongly related to the occurrence of total complication (odds ratio [OR] 8.13, 95% CI 5.75-12.20) and of major complications (OR 4.03, 95% CI 2.38-7.35). The occurrence of minor complications was independently related to surgery (OR 7.33, 95% CI 4.75-11.02), childhood (OR 1.52, 95% CI 1.01-2.34), and presence of systemic hypertension (OR 1.35, 95% CI 1.01-4.41). Hospital stay was shorter in group B (3.2 ± 0.9 vs 8.0 ± 2.8 days, P <.0001). Conclusions: Percutaneous ASD closure provides, in experienced hands and in highly specialized centers, excellent results with a lower complication rate and requires a shorter stay in hospital.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalAmerican Heart Journal
Issue number1
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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