Percutaneous vertebroplasty in multiple myeloma: Prospective long-term follow-up in 106 consecutive patients

Giovanni Carlo Anselmetti, Antonio Manca, Filippo Montemurro, Joshua Hirsch, Gabriele Chiara, Giovanni Grignani, Fabrizio Carnevale Schianca, Antonio Capaldi, Delia Rota Scalabrini, Elena Sardo, Felicino Debernardi, Gabriella Iussich, Daniele Regge

Research output: Contribution to journalArticle

Abstract

Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalCardioVascular and Interventional Radiology
Volume35
Issue number1
DOIs
Publication statusPublished - Feb 2012

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Vertebroplasty
Multiple Myeloma
Compression Fractures
Braces
Bone Cements
Pain Measurement
Back Pain
Visual Analog Scale
Opioid Analgesics
Osteoporosis
Analgesics
Therapeutics
Neoplasm Metastasis
Safety
Pain
Injections

Keywords

  • Interventional radiology
  • Myeloma
  • Pain treatment
  • Quality of Life
  • Vertebroplasty

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Percutaneous vertebroplasty in multiple myeloma : Prospective long-term follow-up in 106 consecutive patients. / Anselmetti, Giovanni Carlo; Manca, Antonio; Montemurro, Filippo; Hirsch, Joshua; Chiara, Gabriele; Grignani, Giovanni; Carnevale Schianca, Fabrizio; Capaldi, Antonio; Rota Scalabrini, Delia; Sardo, Elena; Debernardi, Felicino; Iussich, Gabriella; Regge, Daniele.

In: CardioVascular and Interventional Radiology, Vol. 35, No. 1, 02.2012, p. 139-145.

Research output: Contribution to journalArticle

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abstract = "Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82{\%} (range 36-89{\%}) significantly improved to 7{\%} (range 0-82{\%}) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86{\%}) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.",
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T1 - Percutaneous vertebroplasty in multiple myeloma

T2 - Prospective long-term follow-up in 106 consecutive patients

AU - Anselmetti, Giovanni Carlo

AU - Manca, Antonio

AU - Montemurro, Filippo

AU - Hirsch, Joshua

AU - Chiara, Gabriele

AU - Grignani, Giovanni

AU - Carnevale Schianca, Fabrizio

AU - Capaldi, Antonio

AU - Rota Scalabrini, Delia

AU - Sardo, Elena

AU - Debernardi, Felicino

AU - Iussich, Gabriella

AU - Regge, Daniele

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N2 - Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.

AB - Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.

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