TY - JOUR
T1 - Percutaneous vertebroplasty in multiple myeloma
T2 - Prospective long-term follow-up in 106 consecutive patients
AU - Anselmetti, Giovanni Carlo
AU - Manca, Antonio
AU - Montemurro, Filippo
AU - Hirsch, Joshua
AU - Chiara, Gabriele
AU - Grignani, Giovanni
AU - Carnevale Schianca, Fabrizio
AU - Capaldi, Antonio
AU - Rota Scalabrini, Delia
AU - Sardo, Elena
AU - Debernardi, Felicino
AU - Iussich, Gabriella
AU - Regge, Daniele
PY - 2012/2
Y1 - 2012/2
N2 - Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.
AB - Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P <0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P <0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P <0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P <0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.
KW - Interventional radiology
KW - Myeloma
KW - Pain treatment
KW - Quality of Life
KW - Vertebroplasty
UR - http://www.scopus.com/inward/record.url?scp=84856861858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856861858&partnerID=8YFLogxK
U2 - 10.1007/s00270-011-0111-4
DO - 10.1007/s00270-011-0111-4
M3 - Article
C2 - 21305282
AN - SCOPUS:84856861858
VL - 35
SP - 139
EP - 145
JO - CardioVascular and Interventional Radiology
JF - CardioVascular and Interventional Radiology
SN - 7415-5101
IS - 1
ER -