Perforin gene prf1 c.900c> t polymorphism and hiv-1 vertical transmission

Luisa Zupin, Vania Polesello, Anselmo Jiro Kamada, Rossella Gratton, Ludovica Segat, Louise Kuhn, Sergio Crovella

Research output: Contribution to journalArticlepeer-review


Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C > T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C > T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C > T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.

Original languageEnglish
Pages (from-to)574-577
Number of pages4
JournalGenetics and Molecular Biology
Issue number3
Publication statusPublished - Jul 1 2019


  • HIV-1 susceptibility
  • Perforin
  • PRF1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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