Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

Flora H. Duits, Pablo Martinez-Lage, Claire Paquet, Sebastiaan Engelborghs, Alberto Lleó, Lucrezia Hausner, José L. Molinuevo, Erik Stomrud, Lucia Farotti, Inez H G B Ramakers, Magda Tsolaki, Constance Skarsgård, Ragnar Åstrand, Anders Wallin, Martin Vyhnalek, Marie Holmber-Clausen, Orestes V. Forlenza, Laura Ghezzi, Martin Ingelsson, Erik I. HoffGerwin Roks, Alexandre De Mendonça, Janne M. Papma, Andrea Izagirre, Mariko Taga, Hanne Struyfs, Daniel A. Alcolea, Lutz Frölich, Mircea Balasa, Lennart Minthon, Jos W R Twisk, Staffan Persson, Henrik Zetterberg, Wiesje M. Van Der Flier, Charlotte E. Teunissen, Philip Scheltens, Kaj Blennow

Research output: Contribution to journalArticle

Abstract

Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.

Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalAlzheimer's and Dementia
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Spinal Puncture
Feasibility Studies
Headache
Punctures
Back Pain
Needles
Cerebrospinal Fluid
Logistic Models
Regression Analysis
Incidence
Population

Keywords

  • Alzheimer's disease
  • Cognitive disorders
  • Lumbar puncture
  • Memory clinic
  • Multicenter study on LP feasibility
  • Post-LP complications
  • Post-LP headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Duits, F. H., Martinez-Lage, P., Paquet, C., Engelborghs, S., Lleó, A., Hausner, L., ... Blennow, K. (2016). Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study. Alzheimer's and Dementia, 12(2), 154-163. https://doi.org/10.1016/j.jalz.2015.08.003

Performance and complications of lumbar puncture in memory clinics : Results of the multicenter lumbar puncture feasibility study. / Duits, Flora H.; Martinez-Lage, Pablo; Paquet, Claire; Engelborghs, Sebastiaan; Lleó, Alberto; Hausner, Lucrezia; Molinuevo, José L.; Stomrud, Erik; Farotti, Lucia; Ramakers, Inez H G B; Tsolaki, Magda; Skarsgård, Constance; Åstrand, Ragnar; Wallin, Anders; Vyhnalek, Martin; Holmber-Clausen, Marie; Forlenza, Orestes V.; Ghezzi, Laura; Ingelsson, Martin; Hoff, Erik I.; Roks, Gerwin; De Mendonça, Alexandre; Papma, Janne M.; Izagirre, Andrea; Taga, Mariko; Struyfs, Hanne; Alcolea, Daniel A.; Frölich, Lutz; Balasa, Mircea; Minthon, Lennart; Twisk, Jos W R; Persson, Staffan; Zetterberg, Henrik; Van Der Flier, Wiesje M.; Teunissen, Charlotte E.; Scheltens, Philip; Blennow, Kaj.

In: Alzheimer's and Dementia, Vol. 12, No. 2, 01.02.2016, p. 154-163.

Research output: Contribution to journalArticle

Duits, FH, Martinez-Lage, P, Paquet, C, Engelborghs, S, Lleó, A, Hausner, L, Molinuevo, JL, Stomrud, E, Farotti, L, Ramakers, IHGB, Tsolaki, M, Skarsgård, C, Åstrand, R, Wallin, A, Vyhnalek, M, Holmber-Clausen, M, Forlenza, OV, Ghezzi, L, Ingelsson, M, Hoff, EI, Roks, G, De Mendonça, A, Papma, JM, Izagirre, A, Taga, M, Struyfs, H, Alcolea, DA, Frölich, L, Balasa, M, Minthon, L, Twisk, JWR, Persson, S, Zetterberg, H, Van Der Flier, WM, Teunissen, CE, Scheltens, P & Blennow, K 2016, 'Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study', Alzheimer's and Dementia, vol. 12, no. 2, pp. 154-163. https://doi.org/10.1016/j.jalz.2015.08.003
Duits, Flora H. ; Martinez-Lage, Pablo ; Paquet, Claire ; Engelborghs, Sebastiaan ; Lleó, Alberto ; Hausner, Lucrezia ; Molinuevo, José L. ; Stomrud, Erik ; Farotti, Lucia ; Ramakers, Inez H G B ; Tsolaki, Magda ; Skarsgård, Constance ; Åstrand, Ragnar ; Wallin, Anders ; Vyhnalek, Martin ; Holmber-Clausen, Marie ; Forlenza, Orestes V. ; Ghezzi, Laura ; Ingelsson, Martin ; Hoff, Erik I. ; Roks, Gerwin ; De Mendonça, Alexandre ; Papma, Janne M. ; Izagirre, Andrea ; Taga, Mariko ; Struyfs, Hanne ; Alcolea, Daniel A. ; Frölich, Lutz ; Balasa, Mircea ; Minthon, Lennart ; Twisk, Jos W R ; Persson, Staffan ; Zetterberg, Henrik ; Van Der Flier, Wiesje M. ; Teunissen, Charlotte E. ; Scheltens, Philip ; Blennow, Kaj. / Performance and complications of lumbar puncture in memory clinics : Results of the multicenter lumbar puncture feasibility study. In: Alzheimer's and Dementia. 2016 ; Vol. 12, No. 2. pp. 154-163.
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T2 - Results of the multicenter lumbar puncture feasibility study

AU - Duits, Flora H.

AU - Martinez-Lage, Pablo

AU - Paquet, Claire

AU - Engelborghs, Sebastiaan

AU - Lleó, Alberto

AU - Hausner, Lucrezia

AU - Molinuevo, José L.

AU - Stomrud, Erik

AU - Farotti, Lucia

AU - Ramakers, Inez H G B

AU - Tsolaki, Magda

AU - Skarsgård, Constance

AU - Åstrand, Ragnar

AU - Wallin, Anders

AU - Vyhnalek, Martin

AU - Holmber-Clausen, Marie

AU - Forlenza, Orestes V.

AU - Ghezzi, Laura

AU - Ingelsson, Martin

AU - Hoff, Erik I.

AU - Roks, Gerwin

AU - De Mendonça, Alexandre

AU - Papma, Janne M.

AU - Izagirre, Andrea

AU - Taga, Mariko

AU - Struyfs, Hanne

AU - Alcolea, Daniel A.

AU - Frölich, Lutz

AU - Balasa, Mircea

AU - Minthon, Lennart

AU - Twisk, Jos W R

AU - Persson, Staffan

AU - Zetterberg, Henrik

AU - Van Der Flier, Wiesje M.

AU - Teunissen, Charlotte E.

AU - Scheltens, Philip

AU - Blennow, Kaj

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N2 - Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.

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